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Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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[H]ard|Folding News Articles
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Stanford releases Nvidia/Ati compatible Memtest
King_N
[H]ard|Folding Administrator


Posts: 55
Points: 716,115
Work Units: 2,503

Posted: Tue Aug 24, 2010 10:51 pm
Stanford has released a utility called MemtestCL. This utility is compatible with both Nvidia and ATI based video cards.

Quote:
One of our concerns at Folding@home is the reliability of returned results - when you run on hundreds of thousands of machines around the world, in diverse environments, it's virtually guaranteed that some machines will be faulty. We've long advocated the use of reliability-verification tools to make sure your machine is working properly, especially for users who overclock their machines. While good utilities are available for this task on CPUs and system RAM (e.g., StressCPU and Memtest86), few tools are available for these tasks on GPUs because of their relative novelty.

Last year, we released the MemtestG80 GPU memory checker, an analog to Memtest86 for NVIDIA CUDA-enabled GPUs. This has been widely used by the community to catch misbehaving video cards. To bring this testing capability to a wider audience, we've just released a new, OpenCL-based GPU memory tester named MemtestCL. Because it's based on OpenCL, users of ATI video cards (Radeon 4000 series and newer) are now able to validate their GPU memory as well as users of Nvidia video cards. Both MemtestG80 (CUDA) and MemtestCL (OpenCL) implement the test patterns from Memtest86 (as well as a couple custom patterns) to make sure your GPU memory is working correctly.


Download here

GPU3 open beta test continuing well
King_N
[H]ard|Folding Administrator


Posts: 55
Points: 716,115
Work Units: 2,503

Posted: Sun Jul 25, 2010 07:12 am
Stanford is continuing work on the gpu3 client and ati port.

Quote:
I wanted to post an update on our GPU3 beta test. It is going well, so we have put the GPU3 client on our high performance client download page. This new client is required for all Fermi hardware, but also allows pre-Fermi NVIDIA GPUs to access the new GPU3 cores. These cores are labeled core15 (which has already been extensively tested and is in production right now) as well as a new core16 which will be appearing in testing in the coming weeks.

We are also working to finish our OpenCL port for ATI GPUs to support GPU3 on ATI, but there are still performance issues for OpenCL on both NVIDIA and ATI which are holding back this release. You can see more information about the key software behind the GPU3 cores at the OpenMM project website. If you're curious, there is openCL code there for NVIDIA and ATI and we invite the open source OpenCL community to check out this code and see how they can help if interested (note the code is released under an LGPL license).


Improving Understanding Of Protein Folding
King_N
[H]ard|Folding Administrator


Posts: 55
Points: 716,115
Work Units: 2,503

Posted: Fri Jun 25, 2010 09:48 am
Quote:
Physicists at UC Santa Barbara have created a microscopic device to assist biologists in making very fast molecular measurements that aid the understanding of protein folding. This development may help elucidate biological processes associated with diseases such as Alzheimer's and Parkinson's. Since proteins in the body perform different functions according to their shape, the folding process is considered a key area of study.


Full article here
Databases, Stats, and Functions, oh my
King_N
[H]ard|Folding Administrator


Posts: 55
Points: 716,115
Work Units: 2,503

Posted: Mon May 24, 2010 02:59 pm
This last month was spent on improving more of the site functions, the overall speed has increased and everything is appearing to load much faster now.

During this time Smokerngs brought to my attention that there was a glitch with the stats leftover from the stanford stats upgrade, the problem has been tracked and fixed, everything should once again be functioning as normal.
Support for GTX 4xx hardware
King_N
[H]ard|Folding Administrator


Posts: 55
Points: 716,115
Work Units: 2,503

Posted: Fri Apr 23, 2010 06:37 pm
Stanford is now working on a GTX 4.x client

Quote:
We have been working behind the scenes to optimize the Folding@home GPU client for the new NVIDIA GTX 4xx hardware. So far, it's been going well with us hitting some strong performance numbers. We are internally testing this and hope to soon (weeks) release this for outside beta testing. Please note that GTX 4xx support will require a new client and also requires some changes to our cluster backend software.


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