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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Xiaowei Zhuang makes snuff films. First,....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,855,635
Work Units: 6,694

Posted: Wed Aug 03, 2005 12:44 pm
Xiaowei Zhuang makes snuff films. First, she isolates her victims. Then she forces them into a closed chamber, surrounds them with known killers, and lets her camera run.

A couple of years ago, she won a MacArthur "genius" award for her grisly work. At 33, she's a beacon in her field, winner of more than a dozen prizes worldwide. And, no, she didn't go to film school.

Zhuang is a biophysicist. Her movie studio is a state-of-the art laboratory at Harvard, where she works as an assistant professor. Her crew is composed of 15 postdocs and grad students. And her cast? The victims are live monkey cells. The killers are influenza viruses.

Full Story Here
http://www.wired.com/wired/archive/13.08/molecular.html

Resource: Mayhem33
When Dr. James Baker returned from the f....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,855,635
Work Units: 6,694

Posted: Tue Jul 26, 2005 08:20 pm
When Dr. James Baker returned from the first Gulf War in 1991, his University of Michigan colleagues must have assumed the medical researcher's head had sustained a direct Scud missile hit. The good doctor came home with some pretty wacky ideas.

Here was one of them: Instead of using live viruses to destroy diseased cells, why not send in man-made, nanoscale molecules with tiny tendrils that scientists could engineer to battle specific types of cancers?

Full story here
http://www.wired.com/news/medtech/0,1286,68195,00.html?tw=wn_tophead_1

Resource: Mayhem33

SYDNEY (AFP) - Australian scientists hav....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,855,635
Work Units: 6,694

Posted: Mon Jul 11, 2005 07:08 pm
SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs.

ADVERTISEMENT

Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides.

Full story here http://news.yahoo.com/news?tmpl=story&u=/afp/20050707/hl_afp/scienceaustralia
CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,855,635
Work Units: 6,694

Posted: Fri Jun 10, 2005 10:23 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way it is completely run by members of the team.

See this link for details.

http://www.hardforum.com/showthread.php?t=909819

Resource: Viper87227
DC in the May 6th Issue of Science

DI....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,855,635
Work Units: 6,694

Posted: Tue May 24, 2005 01:17 pm
DC in the May 6th Issue of Science

DISTRIBUTED COMPUTING:
Grassroots Supercomputing

Democratizing science?
Stanford's Pande, who models how proteins fold, was among the first scientists to ride the public-resource computing wave. Proteins are like self-assembling puzzles for which we know all the pieces (the sequence of amino acids in the protein backbone) as well as the final picture (their shape when fully folded), but not what happens in between. It only takes microseconds for a typical protein to fold itself up, but figuring out how it does it is a computing nightmare. Simulating nano-second slices of folding for a medium-sized protein
requires an entire day of calculation on the fastest machines and years to finish the job. Breaking through what Pande calls "the microsecond barrier" would not only help us understand the physical chemistry of normal proteins, but it could also shed light on the many diseases caused by misfolding, such as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease.

Full artical located here

http://www.sciencemag.org/cgi/content/full/308/5723/810

Resource: Spectre
  • Stickies: 0
  • News Articles: 158
  • Pages: 32
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