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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Metastasis more likely to occur with clusters of circulating tumor cells rather than single cells
New type of cell movement discovered
Research reveals mechanism behind cell protein remodeling within a family of cancers
How high-fat diets promote intestinal cancer
How premalignant cells can sense oncogenesis and halt growth
Exploiting a common cancer defense shows promise as a new cancer therapy
Targeted therapy for hepatocellular carcinoma using nanotechnology and the thunder god vine
New ESC registries launched on cardiac oncology and ACS
Leading scientists call for a stop to non-essential use of fluorochemicals
Versatile multi-tasking nanoparticles offer a wide variety of diagnostic and therapeutic applications
Acoustic device that separates tumor cells from blood cells could help assess cancer's spread
Sound waves separate tumor and blood cells
Probing cancer's molecular make-up
New approach to treating cancer: personalized radiation therapy during - instead of after - cancer surgery
Knowledge is power: UCLA study finds men who are uneducated about their prostate cancer have difficulty making good treatment choices
Gentle separation of cells using tilted acoustic tweezers
The epigenetic signature could be key to glioblastoma's therapeutic resistance
Potential for early attack on malaria offered by cancer-fighting drugs
Depression untreated in many cancer patients, new approach could help
Discovery of navigation system used by cancer, nerve cells
New approach developed to identify 'drivers' of cancer
Cutting the liver piece by piece gives hope to patients with cancer that has spread from the intestine
Leukemia and other cancers could be treated more effectively with drug used for DNA repair defects
Study shows a direct correlation between smoking and mortality
Insights into the cancer epigenome have implications for treatment, prevention
Memory boosted by electric current to brain: finding has implications for stroke, Alzheimer's and brain injury
Marijuana compound shows promise for treating Alzheimer's disease in preclinical study
Unprecedented detail of intact neuronal receptor should serve as template and guide for the design of therapeutic compounds
Mindfulness training can improve quality of life for memory impaired and their caregivers
Weight loss following bariatric surgery leads to improved brain function, could reduce risk of Alzheimer's in obese people
APOE, diagnostic accuracy of CSF biomarkers for Alzheimer disease
Missing protein associated with early signs of dementia
Research underway to create pomegranate drug to stem Alzheimer's and Parkinson's
Cognitive impairment increases risk of stroke
Retinal thinning can be used as an early marker for frontotemporal dementia, prior to the onset of cognitive symptoms
Cognitive impairment 'associated with a higher risk of stroke'
New mouse line offers new insights for treatments of epilepsy, Alzheimer's
Alzheimer's disease: rAAV/ABAD-DP-6His attenuates oxidative stress induced injury of PC12 cells
Dementia risk increased for obese people in 30s, but reduced for obese seniors
Pulse pressure and elasticity of arteries in the brain mapped for arterial health and aging
Alzheimer's disease: are we close to finding a cure?
Zebrafish help to unravel Alzheimer's disease
Atypical antipsychotic drug use increases risk for acute kidney injury
Examining the brain's chromosomal make-up in relation to Alzheimer's disease
DNA methylation in brain 'linked to Alzheimer's disease'
Researchers find RNA-targeted drug candidate for Lou Gehrig's disease
Understanding of Alzheimer's disease improved by epigenetic breakthrough
Jet lag controlled by a single gene
Protein implicated in Alzheimer's disease has important treatment potential in genetic form of epilepsy
Decreased brain activity in Alzheimer's disease leads to decline in daily functioning
New type of cell movement discovered
Research reveals mechanism behind cell protein remodeling within a family of cancers
Artificial virus improves delivery of new generations of pharmaceuticals
Stem cell breakthrough for 'Cinderella cells'
Neanderthals and modern humans co-existed for thousands of years
Scientists grow fully functional thymus in mice from scratch
MRC publishes a review of the UK molecular pathology landscape
One of the biggest challenges for single-cell research is picking out only one cell from a collection of millions - problem solved
Treating pain by blocking the 'chili-pepper receptor'
Slippery material for lubricating joints inspired by nature
Scripps research institute chemists uncover powerful new click chemistry reactivity
Parasitic worms sniff out their victims as "cruisers" or "ambushers"
Scientists build first functional 3D brain tissue model
"Dimmer switch" drug idea could tackle schizophrenia
Cell signaling pathway linked to obesity and Type 2 diabetes
Probes that repair genes inspired by butterfly proboscis
The speed of a signal seals the fate of an embryonic cell
Scientists reproduce evolutionary changes by manipulating embryonic development of mice
New insights into why adolescents carry meningitis-causing bacteria
Self-assembling anti-cancer molecules created in minutes, like a self-assembling 'Lego Death Star'
Softening of human features 'coincided with technological breakthrough'
Chemists create nanofibers using unprecedented new method
Wound closure involves cooperative compression
Biomedical discoveries accelerated by see-through organs and bodies
Advances in maritime anti-fouling and biomedicine provided by barnacle cyprid adhesives
  • Stickies: 0
  • News Articles: 158
  • Pages: 32
Xiaowei Zhuang makes snuff films. First,....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,845,417
Work Units: 6,667

Posted: Wed Aug 03, 2005 12:44 pm
Xiaowei Zhuang makes snuff films. First, she isolates her victims. Then she forces them into a closed chamber, surrounds them with known killers, and lets her camera run.

A couple of years ago, she won a MacArthur "genius" award for her grisly work. At 33, she's a beacon in her field, winner of more than a dozen prizes worldwide. And, no, she didn't go to film school.

Zhuang is a biophysicist. Her movie studio is a state-of-the art laboratory at Harvard, where she works as an assistant professor. Her crew is composed of 15 postdocs and grad students. And her cast? The victims are live monkey cells. The killers are influenza viruses.

Full Story Here
http://www.wired.com/wired/archive/13.08/molecular.html

Resource: Mayhem33
When Dr. James Baker returned from the f....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,845,417
Work Units: 6,667

Posted: Tue Jul 26, 2005 08:20 pm
When Dr. James Baker returned from the first Gulf War in 1991, his University of Michigan colleagues must have assumed the medical researcher's head had sustained a direct Scud missile hit. The good doctor came home with some pretty wacky ideas.

Here was one of them: Instead of using live viruses to destroy diseased cells, why not send in man-made, nanoscale molecules with tiny tendrils that scientists could engineer to battle specific types of cancers?

Full story here
http://www.wired.com/news/medtech/0,1286,68195,00.html?tw=wn_tophead_1

Resource: Mayhem33

SYDNEY (AFP) - Australian scientists hav....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,845,417
Work Units: 6,667

Posted: Mon Jul 11, 2005 07:08 pm
SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs.

ADVERTISEMENT

Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides.

Full story here http://news.yahoo.com/news?tmpl=story&u=/afp/20050707/hl_afp/scienceaustralia
CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,845,417
Work Units: 6,667

Posted: Fri Jun 10, 2005 10:23 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way it is completely run by members of the team.

See this link for details.

http://www.hardforum.com/showthread.php?t=909819

Resource: Viper87227
DC in the May 6th Issue of Science

DI....
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,845,417
Work Units: 6,667

Posted: Tue May 24, 2005 01:17 pm
DC in the May 6th Issue of Science

DISTRIBUTED COMPUTING:
Grassroots Supercomputing

Democratizing science?
Stanford's Pande, who models how proteins fold, was among the first scientists to ride the public-resource computing wave. Proteins are like self-assembling puzzles for which we know all the pieces (the sequence of amino acids in the protein backbone) as well as the final picture (their shape when fully folded), but not what happens in between. It only takes microseconds for a typical protein to fold itself up, but figuring out how it does it is a computing nightmare. Simulating nano-second slices of folding for a medium-sized protein
requires an entire day of calculation on the fastest machines and years to finish the job. Breaking through what Pande calls "the microsecond barrier" would not only help us understand the physical chemistry of normal proteins, but it could also shed light on the many diseases caused by misfolding, such as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease.

Full artical located here

http://www.sciencemag.org/cgi/content/full/308/5723/810

Resource: Spectre
  • Stickies: 0
  • News Articles: 158
  • Pages: 32
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