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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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 Boingo04/17/14 
Poor kidney function may boost cancer risk
Death rates from pancreatic cancer are rising while rates for all other cancers, except female lung cancer, continue to fall in Europe
'Dustman' protein helps bin cancer cells
Scientists find key steps linking dietary fats and colon cancer tumor growth
Fast, simple-to-use assay reveals the 'family tree' of cancer metastases
Gene within gene drives acute myeloid leukemia, says new study
FDA approves Cyramza for stomach cancer
The source identified of most cases of invasive bladder cancer
As genomic medicine expands, computational method dramatically speeds up estimates of gene expression
How peripheral pain occurs in nerves suggests new targets for pain relief
Advanced abdominal cancer: 20 years of data shows treatment technique improvement
Living devices may selectively kill cancer cells without disrupting healthy cells
Chronic prostate inflammation tied to nearly double risk of prostate cancer
Key cell division proteins also power up mitochondria; finding could influence cancer care and regenerative medicine
Non-stem cells may naturally replace lost stem cells; findings have implications for understanding cancer
Dedicated immune cells defend a single organ
Technique developed to reverse engineer cells may lead to therapeutic targets for disease
Research represents novel approach to lessening impact of Alzheimer's, Parkinson's
Off-the-shelf vaccine targeting dendritic cells can safely lead to robust humoral and cellular immunity
Isolating immune cells to study how they ward off oral diseases
Refined categorization may improve prediction of patient survival in RECIST 1.1
Blocking protein partnership has implications for cancer treatment
Ovarian cancer patients may benefit from nanoparticles designed to deliver three cancer drugs at a time
Gene variant makes eaters of processed meat 'more likely to get colorectal cancer'
Teens who conform to gender norms 'more likely to engage in cancer-risk behaviors'
Longer education linked to better recovery from traumatic brain injury
New approach 'DICE' may help manage the most troubling symptoms of dementia, lessen use of drugs
Mild cognitive impairment linked to early death in new research
Potential new approach to Alzheimer's treatment offered by 'Chaperone' compounds
New approach to Alzheimer's treatment found in novel class of compounds
Research represents novel approach to lessening impact of Alzheimer's, Parkinson's
Researchers discover brain activity that may mark memory formation
Neuroscientists explain how memories stick together
Apathy in older adults linked to increased brain shrinkage
Modified stem cells may offer way to treat Alzheimer's disease
Gene variant gives women higher risk for Alzheimer's
Alzheimer's disease research could be revolutionized by new mouse model
Could Silly Putty help treat neurological disorders?
Researchers at the University of Valencia discover new molecules against Alzheimer's disease
Improving cognition later in life through physical activity
Innovative, coordinated brain care could save billions of health care dollars
Why is there an inverse association between cancer and Alzheimer's?
New dementia care models to improve care for older adults with Alzheimer's disease
Working memory boosted by green tea
Caring for grandkids once a week keeps grandmas sharp
Presymptomatic diagnosis of Alzheimer's disease will alter life with a 'brain at risk'
Likely connection between white matter and cognitive health
2 new studies find no evidence of Alzheimer's disease-associated changes in adolescents carrying genetic risk factors
African Americans may be at a greatly increased risk for Alzheimer's disease
Complex relationship between slow-wave sleep and odor memory revealed
Simulating in tiny steps gave birth to long-sought-after method of drug development
The anti-inflammatory factory - how lipid mediators are produced
Fast, simple-to-use assay reveals the 'family tree' of cancer metastases
Vanderbilt study tracks new lung cancer drug target
Large number of antibiotic resistance genes discovered in cow manure
Stem cells show bizarre absorption property 'not seen before in cells'
New approach to Alzheimer's treatment found in novel class of compounds
Nature Bank opens the door to unlimited opportunities, starting with Parkinson's disease
Key 'sperm meets egg' protein discovery holds promise for fertility treatments
Research shows processing can affect size of nano carriers for targeted drug delivery
Study on Mt. Everest shows how people get type 2 diabetes
Virus-fighting genes linked to mutations in cancer: Genetic evidence supports role of gene family in cancer development
Researchers at the University of Valencia discover new molecules against Alzheimer's disease
Key to stronger, more effective antibiotics could be enzyme 'wrench'
New target in flu virus may open route to better drugs
Obsessive-compulsive disorder may reflect a propensity for bad habits
Team solves decades-old mystery of how cells keep from bursting
Researchers demonstrates advantages of the HOPE fixation strategy
How does the 'kissing disease' replicate itself?
Identification of <em>pelo</em>, a host gene needed for efficient virus production
New agents may revitalize antibiotics to fight superbugs
Higher blood pressure is linked to a lower tendency to worry
Method offers potential for understanding anti-bacterial resistance
Scientists discover key cells involved in touch sensation
The hormone that allows us to love may also encourage us to lie
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Members are currently setting up a race,....
King_N
[H]ard|Folding Administrator


Posts: 98
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Posted: Fri May 20, 2005 11:41 pm
Members are currently setting up a race, more details located here

http://hardforum.com/showthread.php?s=5a2b4125feda96e156e38a2196958fff&t=905746
The [H]orde has reclaimed #1 in the Fold....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,740,251
Work Units: 6,437

Posted: Thu Apr 21, 2005 03:50 pm
The [H]orde has reclaimed #1 in the Folding@Home project.

Great work everyone.

Get your [H]orde Case Badges now.

Inf....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,740,251
Work Units: 6,437

Posted: Wed Mar 30, 2005 02:10 am
Get your [H]orde Case Badges now.

Info located here;

http://www.hardforum.com/showthread.php?t=883244
Stanford researchers have developed a co....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,740,251
Work Units: 6,437

Posted: Mon Mar 28, 2005 12:13 pm
Stanford researchers have developed a color-coded method for determining whether a protein has folded or unfolded by attaching it to gold nanoparticles.

Full story located here.
http://www.wired.com/news/medtech/0,1286,67028,00.html?tw=rss.TOP

Resource: PoisonedPawn45

CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,740,251
Work Units: 6,437

Posted: Thu Feb 17, 2005 04:03 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way.

See this link for details.

http://www.hardforum.com/showthread.php?t=842054

Resource: Viper87227
  • Stickies: 0
  • News Articles: 153
  • Pages: 31
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