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Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Cancer News
Software May Allow Doctors To Track Progression Of Cancer, Response To Treatment, And Risk Of Relapse
Outcome In Head And Neck Cancer Predicted By Genetic Diversity Within Tumors
Cancer Survivors Suffer Physical & Emotional Impairments Which Often Go Untreated
UK Aims To Make Genetic Testing Available To All Cancer Patients
Depressive Symptoms Are Linked To Early Death In Cancer Survivors
Non-Surgical Treatments For Multiple Tumors Move One Step Closer
Study Finds Broad Support For Rationing Of Some Types Of Cancer Care
Advanced Prostate Cancer Drug Xofigo Approved By FDA
Study Suggests Cutaneous Squamous Cell Carcinoma Carries Risk Of Metastasis And Death
Data Addressing Patient And Physician Barriers To Clinical Trials To Be Presented By Experts
Bankruptcy An Increased Risk Following Cancer Diagnosis
Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma
Molecular Profiling Timely For Tailoring Cancer Therapy
Exercise Lowers Risk Of Lung And Colorectal Cancer Among Middle Aged Men
Early Stage Testicular Cancer - Surveillance Is Best Follow-Up Strategy
Study Findings May Offer New Way To Kill Cancer Cells By Forcing Them Into An Alternative Programmed Death Pathway
In Preclinical Studies, New Drug Enhances Radiation Treatment For Brain Cancer
Chemists Demonstrate Nanoscale Alloys So Bright They Could Have Potential Medical Applications
FDA Approves New Lung Cancer Diagnostic "Cobas EGFR Mutation Test"
Cancer Metastasis Promoted By Tumor-Activated Protein
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Shared Decision Making And How Decision Aids Help Guide Choices For Cancer Screening
4 New Genetic Risk Factors Identified For Testicular Cancer
60 Years Of Data Suggest A Link Between Obesity And Height In Childhood And Endometrial Cancer In Adulthood
Link Suggested Between Tumor Suppressors And Starvation Survival
Alzheimer's News
Relationship Discovered Between Sleep Apnea And Alzheimer's Disease
Mediterranean Diet Seems To Boost Ageing Brain Power
News From Frontiers In Endocrinology, Microbiology, Physiology
Skin Cancer Link To Lower Risk Of Alzheimer's Disease, Says Study
Assessing The Efficacy Of Different Types Of Training Programs On Cognitive Performance In Elderly Patients
Detect Alzheimer's Disease Years Before Memory Loss And Cognitive Decline Become Apparent
Drug Improves Memory In Mice With Alzheimer's Disease
Obesity-Related Dementia Is Projected To Rise In England
Leukemia Drug Prevents Build-Up Of Toxic Brain Protein
Mutations In Genes That Regulate Cellular Metabolism Found In Families With Ataxia, Dementia And Reproductive Failure
A Patient's Right To Control Genomic Health Information
Association Between Alzheimer's Disease And Removal Of The Synaptic Protein ADAM10
Scientists Bring Clarity To How Most Alzheimer's Drugs Sharpen Brain Performance
Rethinking Therapeutic Strategies That Target APOE To Slow Amyloid Plaque Accumulation And Alzheimer's
Problems Processing Everyday Events Linked To Older Adults' Memory Lapses
Study Examines Cognitive Impairment In Families With Exceptional Longevity
How Environmental Stimuli And Brain Rhythms Generate Our Neuronal Maps Of The World
Study Finds Late-Life Depression Associated With Increased Risk For Dementia
Early Detection Of Alzheimer's Disease Expected In The Next Five To Ten Years
How Turning Down Synthesis Of A Protein Improves Nerve, Muscle Function In Common Neuropathy
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Potential Therapeutic Targets Revealed For Late Onset Alzheimer's Disease
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Alzheimer's Gene Discovery Offers Hope For Preventive Therapy
Molecular Changes Akin To Alzheimer's Discovered In Brain Following Mild Blast Injury
Biochemistry News
[H]ard|Folding News Articles
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  • News Articles: 142
  • Pages: 29
From the Pande Group / Folding@home foru....
CIWS


Posts: 11
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Posted: Sun Mar 07, 2004 12:00 am
From the Pande Group / Folding@home forums comes this announcement about an additional core that will be issued to work some units.

"Hi,
For certain calculations we have begun, greater precision is required than provided by FahCore_78.exe. To fill this need, we have prepared a new Gromacs core and called it FahCore_79.exe. (For the technically curious, it's identical in most respects, but using doubles rather than floats.)
The new core doesn't replace the old one, but will be used for certain projects. The first project to use it is 930, for which a small number of assignments have gone out. In the coming week, it will likely roll out wider.
Thanks,
Guha"

http://forum.folding-community.org/viewtopic.php?t=7233
First-of-a-kind cancer fighter approved.....
CIWS


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Posted: Thu Mar 04, 2004 12:00 am
First-of-a-kind cancer fighter approved.

The government on Thursday approved the first drug that promises to attack cancer by choking off its blood supply, a colon cancer treatment called Avastin. The drug has only a modest benefit -- it can extend the lives of patients with advanced colon cancer by about five months, the Food and Drug Administration cautioned.
But it\'s a significant development, because Avastin becomes the first drug proved to work according to a novel theory that tumors must form a network of blood vessels to survive -- and that shutting down that process, called angiogenesis, could fight cancer in a manner completely differently than other treatments.


http://www.cnn.com/2004/HEALTH/conditions/02/26/cancer.drug.ap/index.html
Purdue Chemists 'Put The Twist' On....
CIWS


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Posted: Thu Mar 04, 2004 12:00 am
Purdue Chemists 'Put The Twist' On Protein Building Block.

Purdue scientists have made an important biological molecule "swing," in work that might clarify the process by which proteins fold as well as lead to new approaches to drug development and computer memory.
Using lasers to initiate and probe the folding process, a group including chemist Timothy Zwier have precisely determined the energies needed to twist tryptamine, a molecule with several flexible "hinges" that bears a close resemblance to an amino acid, the basis of proteins. Understanding the energy pathways that these molecules take passing from one conformation to another could provide new understanding of the elusive process of protein folding - an essential part of the development of these fundamental biological molecules. And though tryptamine forms only a tiny portion of a protein, a better understanding of this close chemical relative to serotonin and melatonin could provide insights into these other substances' effect on the brain.

http://www.sciencedaily.com/releases/2004/02/040226064833.htm
Vertex Drug Reverses Cancer in Animal St....
CIWS


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Posted: Tue Feb 24, 2004 12:00 am
Vertex Drug Reverses Cancer in Animal Study

A new type of cancer drug stopped tumor growth in an early animal study, boosting hopes that the approach may prove promising in humans, according to data released on Sunday.
The treatment, called VX-680 and being developed by Vertex Pharmaceuticals Inc., represents the first drug to stop tumors by targeting enzymes called Aurora kinases.

http://story.news.yahoo.com/news?tmpl=story&cid=571&ncid=1422&e=2&u=/nm/health_vertex_dc
Friday the 13th was a good day for the [....
relic


Posts: 2
Points: 7,385,172
Work Units: 40,268
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Posted: Mon Feb 16, 2004 12:00 am
Friday the 13th was a good day for the [H]UD team. We passed 150 Million points. Well done [H] UDers! The 1 million results returned milestone is getting close with less that 100k to go.

-relic
  • Stickies: 0
  • News Articles: 142
  • Pages: 29
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