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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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'Pathogenic connection' between cancer and autoimmune disorders
Innovative data collection system for cancer patients developed to improve care and outcomes
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Mapping decade of discovery to potential anticancer agent
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SYDNEY (AFP) - Australian scientists hav....
King_N
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Posted: Mon Jul 11, 2005 07:08 pm
SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs.

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Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides.

Full story here http://news.yahoo.com/news?tmpl=story&u=/afp/20050707/hl_afp/scienceaustralia
CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
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Posted: Fri Jun 10, 2005 10:23 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way it is completely run by members of the team.

See this link for details.

http://www.hardforum.com/showthread.php?t=909819

Resource: Viper87227
DC in the May 6th Issue of Science

DI....
King_N
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Posts: 101
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Posted: Tue May 24, 2005 01:17 pm
DC in the May 6th Issue of Science

DISTRIBUTED COMPUTING:
Grassroots Supercomputing

Democratizing science?
Stanford's Pande, who models how proteins fold, was among the first scientists to ride the public-resource computing wave. Proteins are like self-assembling puzzles for which we know all the pieces (the sequence of amino acids in the protein backbone) as well as the final picture (their shape when fully folded), but not what happens in between. It only takes microseconds for a typical protein to fold itself up, but figuring out how it does it is a computing nightmare. Simulating nano-second slices of folding for a medium-sized protein
requires an entire day of calculation on the fastest machines and years to finish the job. Breaking through what Pande calls "the microsecond barrier" would not only help us understand the physical chemistry of normal proteins, but it could also shed light on the many diseases caused by misfolding, such as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease.

Full artical located here

http://www.sciencemag.org/cgi/content/full/308/5723/810

Resource: Spectre
Members are currently setting up a race,....
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Fri May 20, 2005 11:41 pm
Members are currently setting up a race, more details located here

http://hardforum.com/showthread.php?s=5a2b4125feda96e156e38a2196958fff&t=905746
The [H]orde has reclaimed #1 in the Fold....
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
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Posted: Thu Apr 21, 2005 03:50 pm
The [H]orde has reclaimed #1 in the Folding@Home project.

Great work everyone.

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