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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.

What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.

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Study defines an interaction between key proteins in cell division
Making diagnostic medical imaging safer
Medicare law aimed a reducing chemotherapy cost turned out to have little impact
Discovery of shining cells responsible for developing tumors
Study examines medical professional liability claims related to esophageal cancer screening
Many patients lack information about the use of targeted therapies, oncologists say
Significant presence of women in oncology, but still under-representation in leadership positions, Greek survey shows
What are the top 10 leading causes of death in the US?
Potent new cancer drugs likely with new protein 'map'
Survey reveals emotional exhaustion affects many cancer specialists
New estrogen-related breast cancer mechanism detected
Cancer during pregnancy: chemotherapy and radiotherapy are safe for babies, studies show
Anamorelin shown to improve appetite and body mass in patients with cancer anorexia-cachexia
Second-line afatinib significantly improves progression-free survival in recurrent or metastatic head and neck cancer, phase III trial shows
Rolapitant reduces nausea and vomiting in phase III trial
Strategy to reduce side effects in modern cancer therapy
Taller people at reduced risk of esophageal cancer
Genetic 'instruction set' for antibodies knocks down hepatitis C in mice
Scientists shed light on how to block protein that causes cancer, Alzheimer's
New approach offers hope for patients with autoimmune diseases, bone loss
With some tinkering, anthrax becomes an efficient drug carrier for cancer
Newly discovered marker may lead to early detection of pancreatic cancer
A vitamin D-derivative makes pancreatic tumors vulnerable to chemotherapy
Cancer metastatis may be stopped in its tracks with the help of bacterial "communication system"
Research uncovers tumors self-protection mechanism
Hope of a treatment for deadly genetic disease, MPS IIIB
Protein that causes frontotemporal dementia also implicated in Alzheimer's disease
Remote healthcare for an aging population
Promising Alzheimer's treatment being tested by NeuroEM Therapeutics
Scientists shed light on how to block protein that causes cancer, Alzheimer's
Regeneration of brain stem cells boosted by turmeric compound
The emotion lingers long after the memories have vanished in Alzheimer's patients
Promising drug candidate for Alzheimer's found in turmeric compound
Viewing drugs' effect on living brain now possible with first mouse model for ALS dementia
New 'designer proteins' created in fight against Alzheimer's and cancer
Online resource encourages everyone to improve brain health
Memory complaints could be early indicator of future dementia risk
UK-based chemists report 'designer proteins' breakthrough
Cognitively demanding visual motor task can identify those at high risk for Alzheimer's disease
Down syndrome helps researchers understand Alzheimer's disease
Impaired brain signaling pathway 'may be a cause of Alzheimer's'
World Alzheimer Report 2014: the key points
UB researchers corroborate the neuroprotective effects of Sirtuin 1 activation on mice with Alzheimer's disease
Concussion-related brain disease identified in living brain
Sedentary behavior 'may counteract brain benefits of exercise in older adults'
Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Measuring modified protein structures
The cell recognizes the buildup of misfolded proteins, offers insight into Alzheimer's, ALS, Huntington's, Parkinson's, and type 2 diabetes
Brain may 'work around' early Alzheimer's damage
The young brains of city dwellers harmed by air pollution
Study shows how chimpanzees share skills
Antibiotic exposure associated with early childhood obesity
Customising chemotherapy in lung cancer
Malaria severity influenced by five human genes, say researchers
Scientists shed light on how to block protein that causes cancer, Alzheimer's
Newly discovered marker may lead to early detection of pancreatic cancer
Research uncovers tumors self-protection mechanism
Magnetic field opens and closes nanovesicle
Protein controlling gut's protective force field identified: Immune-system receptor encourages growth of bacterial shield during illness
More evidence that Neanderthals and modern humans overlapped
Diabetes study: investigating fluctuations in blood sugar
Western University researchers explain the highs and lows of marijuana use
UK-based chemists report 'designer proteins' breakthrough
An old drug yields a potential new class of antibiotics
Mechanism of Parkinson's spread demonstrated
Healthy humans 'harbor an average of five viruses'
Pupil size shows reliability of decisions
Endocrine-related protein found to be master regulator in other important diseases
How do I smell? Much the same as how you see
Ebola virus protein offers potential drug target
Glaucoma cure may lie in targeting 'stiff cells' that impede fluid drainage
Is the pattern of brain folding a "fingerprint" for schizophrenia?
Scientists reset human stem cells in 'significant milestone' in medicine
Deactivating a cell protein may halt progress of rheumatoid arthritis
Gene 'may slow aging of entire body when activated in key organs'
  • Stickies: 0
  • News Articles: 159
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New way to monitor your farm/garden usin....
[H]ard|Folding Administrator

Posts: 104
Points: 2,859,398
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Posted: Thu Aug 04, 2005 05:36 pm
New way to monitor your farm/garden using a PSP and EMIII.

Full information can be located here
Xiaowei Zhuang makes snuff films. First,....
[H]ard|Folding Administrator

Posts: 104
Points: 2,859,398
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Posted: Wed Aug 03, 2005 12:44 pm
Xiaowei Zhuang makes snuff films. First, she isolates her victims. Then she forces them into a closed chamber, surrounds them with known killers, and lets her camera run.

A couple of years ago, she won a MacArthur "genius" award for her grisly work. At 33, she's a beacon in her field, winner of more than a dozen prizes worldwide. And, no, she didn't go to film school.

Zhuang is a biophysicist. Her movie studio is a state-of-the art laboratory at Harvard, where she works as an assistant professor. Her crew is composed of 15 postdocs and grad students. And her cast? The victims are live monkey cells. The killers are influenza viruses.

Full Story Here

Resource: Mayhem33
When Dr. James Baker returned from the f....
[H]ard|Folding Administrator

Posts: 104
Points: 2,859,398
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Posted: Tue Jul 26, 2005 08:20 pm
When Dr. James Baker returned from the first Gulf War in 1991, his University of Michigan colleagues must have assumed the medical researcher's head had sustained a direct Scud missile hit. The good doctor came home with some pretty wacky ideas.

Here was one of them: Instead of using live viruses to destroy diseased cells, why not send in man-made, nanoscale molecules with tiny tendrils that scientists could engineer to battle specific types of cancers?

Full story here,1286,68195,00.html?tw=wn_tophead_1

Resource: Mayhem33

SYDNEY (AFP) - Australian scientists hav....
[H]ard|Folding Administrator

Posts: 104
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Posted: Mon Jul 11, 2005 07:08 pm
SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs.


Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides.

Full story here
CPU Contest:

Disclaimer: This contest....
[H]ard|Folding Administrator

Posts: 104
Points: 2,859,398
Work Units: 6,705

Posted: Fri Jun 10, 2005 10:23 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way it is completely run by members of the team.

See this link for details.

Resource: Viper87227
  • Stickies: 0
  • News Articles: 159
  • Pages: 32
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