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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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 Boingo04/17/14 
 DanielGordon04/16/14 
 Huberthans04/15/14 
Off-the-shelf vaccine targeting dendritic cells can safely lead to robust humoral and cellular immunity
Isolating immune cells to study how they ward off oral diseases
Refined categorization may improve prediction of patient survival in RECIST 1.1
Blocking protein partnership has implications for cancer treatment
Ovarian cancer patients may benefit from nanoparticles designed to deliver three cancer drugs at a time
Gene variant makes eaters of processed meat 'more likely to get colorectal cancer'
Teens who conform to gender norms 'more likely to engage in cancer-risk behaviors'
Severe sleep apnea linked to increased risk of stroke, cancer and death
Processing can affect size of nanocarriers for targeted drug delivery
Research shows processing can affect size of nano carriers for targeted drug delivery
Study suggests gene panels as a useful, cheaper alternative to whole-genome sequencing
New blood test 'accurately predicts breast cancer recurrence'
New state-of-the-art educational platform for uro-onco professionals now online
Breakthrough technology to enable doctors to select more effective treatment for cancer patients on a personalised basis
Hepatocellular carcinoma: new advances in diagnosis, staging and treatment all predicted to improve patient outcomes
How and when nerve and brain cells are formed could open doors to targeted cancer therapies
Genetic evidence supports role virus-fighting genes in cancer development
New strategies suggested for kidney regeneration by gene linked to Wilms tumors, a pediatric kidney cancer
ZMYND11 'reads' methylated variant to thwart cancer; tied to breast cancer patient survival
Too much of a protein called c-FLIPR can trigger autoimmune diseases
Tough liver cancer may be treated with immunotherapy
Discovery of latent bioluminescence in fruit flies holds promise for expanded use of bioluminescence imaging tools
3D-printed kidneys could become standard for simulated cancer surgery
Chemotherapy before or after surgery for high-risk bladder cancer improves survival, but is not routinely administered
Virus-fighting genes linked to mutations in cancer: Genetic evidence supports role of gene family in cancer development
Researchers discover brain activity that may mark memory formation
Neuroscientists explain how memories stick together
Apathy in older adults linked to increased brain shrinkage
Modified stem cells may offer way to treat Alzheimer's disease
Gene variant gives women higher risk for Alzheimer's
Alzheimer's disease research could be revolutionized by new mouse model
Could Silly Putty help treat neurological disorders?
Researchers at the University of Valencia discover new molecules against Alzheimer's disease
Improving cognition later in life through physical activity
Innovative, coordinated brain care could save billions of health care dollars
Why is there an inverse association between cancer and Alzheimer's?
New dementia care models to improve care for older adults with Alzheimer's disease
Working memory boosted by green tea
Caring for grandkids once a week keeps grandmas sharp
Presymptomatic diagnosis of Alzheimer's disease will alter life with a 'brain at risk'
Likely connection between white matter and cognitive health
2 new studies find no evidence of Alzheimer's disease-associated changes in adolescents carrying genetic risk factors
African Americans may be at a greatly increased risk for Alzheimer's disease
Complex relationship between slow-wave sleep and odor memory revealed
Green tea may boost our working memory
Scientists discover big clue to how caffeine wards off Alzheimer's
No evidence of Alzheimer's Disease-associated changes in adolescents carrying genetic risk factors
Breakthrough may revolutionize the study of modern-day enzymes
The origin of Lou Gehrig's disease may have just been discovered
How zinc regulates a key enzyme involved in cell death
Nature Bank opens the door to unlimited opportunities, starting with Parkinson's disease
Key 'sperm meets egg' protein discovery holds promise for fertility treatments
Research shows processing can affect size of nano carriers for targeted drug delivery
Study on Mt. Everest shows how people get type 2 diabetes
Virus-fighting genes linked to mutations in cancer: Genetic evidence supports role of gene family in cancer development
Researchers at the University of Valencia discover new molecules against Alzheimer's disease
Key to stronger, more effective antibiotics could be enzyme 'wrench'
New target in flu virus may open route to better drugs
Obsessive-compulsive disorder may reflect a propensity for bad habits
Team solves decades-old mystery of how cells keep from bursting
Researchers demonstrates advantages of the HOPE fixation strategy
How does the 'kissing disease' replicate itself?
Identification of <em>pelo</em>, a host gene needed for efficient virus production
New agents may revitalize antibiotics to fight superbugs
Higher blood pressure is linked to a lower tendency to worry
Method offers potential for understanding anti-bacterial resistance
Scientists discover key cells involved in touch sensation
The hormone that allows us to love may also encourage us to lie
The origin of Lou Gehrig's disease may have just been discovered
Scientists identify protein that spurs spread of colon cancer
Team identifies novel biomarker for head and neck cancer and non-small cell lung cancer
Cell metabolism discovery could spawn treatments for cancer or common cold
Cells measure surface area to know when to divide
Time, trust and transparency keys to minority biospecimen collection
The acrobatic motor protein Kif15 could pave the way for new cancer therapies
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Members are currently setting up a race,....
King_N
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Posted: Fri May 20, 2005 11:41 pm
Members are currently setting up a race, more details located here

http://hardforum.com/showthread.php?s=5a2b4125feda96e156e38a2196958fff&t=905746
The [H]orde has reclaimed #1 in the Fold....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,738,192
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Posted: Thu Apr 21, 2005 03:50 pm
The [H]orde has reclaimed #1 in the Folding@Home project.

Great work everyone.

Get your [H]orde Case Badges now.

Inf....
King_N
[H]ard|Folding Administrator


Posts: 98
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Posted: Wed Mar 30, 2005 02:10 am
Get your [H]orde Case Badges now.

Info located here;

http://www.hardforum.com/showthread.php?t=883244
Stanford researchers have developed a co....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,738,192
Work Units: 6,434

Posted: Mon Mar 28, 2005 12:13 pm
Stanford researchers have developed a color-coded method for determining whether a protein has folded or unfolded by attaching it to gold nanoparticles.

Full story located here.
http://www.wired.com/news/medtech/0,1286,67028,00.html?tw=rss.TOP

Resource: PoisonedPawn45

CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 98
Points: 2,738,192
Work Units: 6,434

Posted: Thu Feb 17, 2005 04:03 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way.

See this link for details.

http://www.hardforum.com/showthread.php?t=842054

Resource: Viper87227
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