Links : [H]ard|Folding [H]ard|OCP
Local

Pacific

Mountain

Central

Eastern

GMT

[H] Member Login

Remember

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



How to Join | Project Faqs | Project Add-ons | Statistics | Download Client
New Members
[ 1 ]
 Bryan_Jackson08/16/14 
Surgery associated with better survival for patients with advanced laryngeal cancer
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
NSAIDs may halve breast cancer recurrence in overweight women
Blueprint for the next generation of chronic myeloid leukemia treatment
NICE clears path for patient access to Revlimid® (lenalidomide) for rare form of blood cancer
Blood test may revolutionize brain cancer diagnosis
Web-based app developed to predict glioma mutations
Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering glioma apoptosis
Dasatinib, a leukemia drug, has the potential to treat many cancers
Gastric cancer: could Botox be an alternative to chemo?
Turkish man pleads guilty to importing illegal cancer drugs
Microfluidic device monitors key step in development of tumor metastases
Myc inhibition is an effective therapeutic strategy against the most aggressive of all brain tumors
Mechanism identified that halts progression of abnormal cells into cancer
In an ecosystem within us, microbes evolved to sway food choices
How tumor cells transition to invasion revealed by microchip
An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1
New ways to treat solid tumours
Older patients with limited life expectancy still receiving cancer screenings
Tumors shrink following bacteria injection
Benefits of vitamin A cancer therapy blocked by a protein
Preventing transplant rejection using stimuli-responsive drug delivery system
C. noyvi-NT shrinks tumors when injected into rats, dogs and humans
For kidney cancer patients, less radical procedures offer similar cancer control compared to surgery
Childhood cancer survivors do not adhere to American Cancer Society's guidelines on healthy living
Dementia risk increased for obese people in 30s, but reduced for obese seniors
Pulse pressure and elasticity of arteries in the brain mapped for arterial health and aging
Alzheimer's disease: are we close to finding a cure?
Zebrafish help to unravel Alzheimer's disease
Atypical antipsychotic drug use increases risk for acute kidney injury
Examining the brain's chromosomal make-up in relation to Alzheimer's disease
DNA methylation in brain 'linked to Alzheimer's disease'
Researchers find RNA-targeted drug candidate for Lou Gehrig's disease
Understanding of Alzheimer's disease improved by epigenetic breakthrough
Jet lag controlled by a single gene
Protein implicated in Alzheimer's disease has important treatment potential in genetic form of epilepsy
Decreased brain activity in Alzheimer's disease leads to decline in daily functioning
Yizhijiannao granules inhibit neuronal apoptosis in Alzheimer's disease
New small molecules target mutation in ALS and a form of dementia
Cognitive decline in older adults may be reduced by digital literacy
Study demonstrates key brain region in contextual memories
New target for treatment of neuronal injury in the hippocampus of rats with vascular dementia
In PC12 cell apoptosis, the role of Notch-1 signaling pathway is induced by amyloid beta-peptide (25-35)
Normal cognition in patient without apolipoprotein E, risk factor for Alzheimer
Some areas of the brain 'may not slow down with aging'
Mild cognitive impairment quadruples risk of dementia
Cognitive decline may increase the risk of stroke
Link found between dementia and vitamin D deficiency
How spiders spin silk has implications for Alzheimer's disease
Changes in hippocampal neurons in animal models of Alzheimer's disease assessed by 7.0T NMR
MRC publishes a review of the UK molecular pathology landscape
One of the biggest challenges for single-cell research is picking out only one cell from a collection of millions - problem solved
Treating pain by blocking the 'chili-pepper receptor'
Slippery material for lubricating joints inspired by nature
Scripps research institute chemists uncover powerful new click chemistry reactivity
Parasitic worms sniff out their victims as "cruisers" or "ambushers"
Scientists build first functional 3D brain tissue model
"Dimmer switch" drug idea could tackle schizophrenia
Cell signaling pathway linked to obesity and Type 2 diabetes
Probes that repair genes inspired by butterfly proboscis
The speed of a signal seals the fate of an embryonic cell
Scientists reproduce evolutionary changes by manipulating embryonic development of mice
New insights into why adolescents carry meningitis-causing bacteria
Self-assembling anti-cancer molecules created in minutes, like a self-assembling 'Lego Death Star'
Softening of human features 'coincided with technological breakthrough'
Chemists create nanofibers using unprecedented new method
Wound closure involves cooperative compression
Biomedical discoveries accelerated by see-through organs and bodies
Advances in maritime anti-fouling and biomedicine provided by barnacle cyprid adhesives
Mouse sperm form cooperative groups
See-through mice may improve diagnosis, treatment of human illness
Video explains why dogs smell each other's behinds
Cancer cells allowed to divide even when oxygen-starved by cell's recycling center
"Killer sperm" prevents mating between worm species
One third of cancer patients are killed by a 'fat-burning' process termed cachexia related to obesity, CNIO researchers say
  • Stickies: 0
  • News Articles: 157
  • Pages: 32
When Dr. James Baker returned from the f....
King_N
[H]ard|Folding Administrator


Posts: 102
Points: 2,838,462
Work Units: 6,651

Posted: Tue Jul 26, 2005 08:20 pm
When Dr. James Baker returned from the first Gulf War in 1991, his University of Michigan colleagues must have assumed the medical researcher's head had sustained a direct Scud missile hit. The good doctor came home with some pretty wacky ideas.

Here was one of them: Instead of using live viruses to destroy diseased cells, why not send in man-made, nanoscale molecules with tiny tendrils that scientists could engineer to battle specific types of cancers?

Full story here
http://www.wired.com/news/medtech/0,1286,68195,00.html?tw=wn_tophead_1

Resource: Mayhem33

SYDNEY (AFP) - Australian scientists hav....
King_N
[H]ard|Folding Administrator


Posts: 102
Points: 2,838,462
Work Units: 6,651

Posted: Mon Jul 11, 2005 07:08 pm
SYDNEY (AFP) - Australian scientists have discovered pineapple molecules can act as powerful anti-cancer agents and said the research could lead to a new class of cancer-fighting drugs.

ADVERTISEMENT

Scientists at the Queensland Institute of Medical Research (QIMR) said their work centred on two molecules from bromelaine, an extract derived from crushed pineapple stems that is used to tenderise meat, clarify beers and tan hides.

Full story here http://news.yahoo.com/news?tmpl=story&u=/afp/20050707/hl_afp/scienceaustralia
CPU Contest:

Disclaimer: This contest....
King_N
[H]ard|Folding Administrator


Posts: 102
Points: 2,838,462
Work Units: 6,651

Posted: Fri Jun 10, 2005 10:23 am
CPU Contest:

Disclaimer: This contest is NOT associated with [H]ardOCP, [H]ardforum, or [H]ardFolding in any way it is completely run by members of the team.

See this link for details.

http://www.hardforum.com/showthread.php?t=909819

Resource: Viper87227
DC in the May 6th Issue of Science

DI....
King_N
[H]ard|Folding Administrator


Posts: 102
Points: 2,838,462
Work Units: 6,651

Posted: Tue May 24, 2005 01:17 pm
DC in the May 6th Issue of Science

DISTRIBUTED COMPUTING:
Grassroots Supercomputing

Democratizing science?
Stanford's Pande, who models how proteins fold, was among the first scientists to ride the public-resource computing wave. Proteins are like self-assembling puzzles for which we know all the pieces (the sequence of amino acids in the protein backbone) as well as the final picture (their shape when fully folded), but not what happens in between. It only takes microseconds for a typical protein to fold itself up, but figuring out how it does it is a computing nightmare. Simulating nano-second slices of folding for a medium-sized protein
requires an entire day of calculation on the fastest machines and years to finish the job. Breaking through what Pande calls "the microsecond barrier" would not only help us understand the physical chemistry of normal proteins, but it could also shed light on the many diseases caused by misfolding, such as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease.

Full artical located here

http://www.sciencemag.org/cgi/content/full/308/5723/810

Resource: Spectre
Members are currently setting up a race,....
King_N
[H]ard|Folding Administrator


Posts: 102
Points: 2,838,462
Work Units: 6,651

Posted: Fri May 20, 2005 11:41 pm
Members are currently setting up a race, more details located here

http://hardforum.com/showthread.php?s=5a2b4125feda96e156e38a2196958fff&t=905746
  • Stickies: 0
  • News Articles: 157
  • Pages: 32
Administrator Council News Member

[H]ard|Folding Copyright © 2001 - 2014 by King_N,   [H]ard|OCP Copyright © 1998 - 2013 by Kyle Bennett

All trademarks used are properties of their respective owners. All rights reserved.