Links : [H]ard|Folding [H]ard|OCP






[H] Member Login


Stanford's goal: to understand protein folding, protein aggregation, and related diseases.

What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.

How to Join | Project Faqs | Project Add-ons | Statistics | Download Client
New Members
[ 3 ]
New strategy to help surgeons see the entire tumor
RNA identified that regulates cell death has implications for cancer
Growth-driving cells within tumors should be targeted, not fastest-proliferating cells
How foremost anticancer 'guardian' protein learned to switch sides
Internal cell fine-tuning discovery may have implications for cancer
'New drug target for leukemia identified'
Breakthrough in measuring how cancer support programs empower survivors
The efficiency of tissue regeneration may be increased by stem cell advance
Blood and saliva test for HPV-related cancers 'in development'
Merck Serono initiates phase II study of anti-PD-L1 antibody MSB0010718C in metastatic Merkel cell carcinoma
Genetic mutations linked to salivary gland tumors
Radiation therapy best practices and quality standards
Endoscopic resection not always best for localized, early-stage esophageal cancer
New test for thyroid cancer increases odds of correct surgery
Some cancer cells are characterized by both high sugar intake and high mobility
Cancer cells allowed to divide even when oxygen-starved by cell's recycling center
Childhood cancer survivors may avoid metabolic syndrome by following a healthy lifestyle
'Five portions of fruit and veg a day are enough'
Could a 'universal' blood test for cancer be on the horizon?
Is the European Union putting cancer research at risk?
Experts at the American Brain Tumor Association's annual conference report findings and dispel myths
Cancer can be driven by epigenetic changes
Nanoparticle stimulate anti-tumor immune responses
SapC-DOPS selectively targets tumor cells in models with brain micrometastases derived from human breast or lung cancer cells
Key molecule identified in flies that adjusts energy use under starvation conditions
Caregivers of dementia sufferers benefit from telephone support program
Number of UK patients with recorded diagnosis of dementia increases by 62 per cent over seven years
Middle-aged adults with a history of problem drinking are more than twice as likely to suffer from severe memory impairment in later life
How is depression related to dementia?
Little-known supportive cells, astrocytes, essential for memory
Researchers discover new protein structure that could help treat Alzheimer's, related diseases
Potential biomarker identified for Alzheimer's disease
UEA research finds hope for more accurate diagnosis of memory problems
Research letter examines pacemaker use in patients with cognitive impairment
Dementia 'predicted by slow walking speed and memory problems'
Protein S100B in blood may trigger brain-damaging immune response
Klotho found to be neuroprotective against Alzheimer's disease
Research letter examines pacemaker use in patients with cognitive impairment
Experiences at every stage of life contribute to cognitive abilities in old age
Dementia carers need more medication support, report says
Treatment identified that prevents tumor metastasis
Cancer drug offers potential for an oral therapy for Alzheimer's disease
New mechanism found for neurodegeneration
Therapies focus on areas of memory and learning in the brain to treat obesity
Deleting enzyme favorably impacts behaviors associated with Fragile X syndrome
Potential genetic link found between epilepsy and neurodegenerative disorders
The future of gene therapy for Alzheimer's disease
Explaining the molecular basis of age-related memory loss
Immune cell discovered that plays neuroprotective role in the brain
Amyloid plaque in Alzheimer's disease may affect remote regions of the brain
Video explains why dogs smell each other's behinds
Cancer cells allowed to divide even when oxygen-starved by cell's recycling center
"Killer sperm" prevents mating between worm species
One third of cancer patients are killed by a 'fat-burning' process termed cachexia related to obesity, CNIO researchers say
Forensic investigations often use dead body feeding larvae
Mathematical modelling could pave way for new chlamydia therapies
High-speed chemical imaging of tissues using enhanced NIST instrument
How gold nanoparticles easily penetrate cells, making them useful for delivering drugs
New light shed on primate biology and evolution
Speedy cell by cell reconstruction of an animal's development made possible by imaging technology
Newly-discovered process helps drosophila cope when temperatures get cold
Distinctive developmental origin for a drainage tube in the eye
Researchers identify more than 80 new genes linked to schizophrenia
Life's imprint on DNA now mappable in single cell
Calorie restriction with resveratrol key to kick-starting cell health
Biomedical technologies may be improved by protein in squid skin
Gene identified that controls the timing of precisely ordered events during maturation
Structure of protein vital to cancer development is mapped
Scientists find ancient protein-building enzymes have undergone metamorphosis and evolved diverse new functions
Findings could revolutionise our understanding of timing during development
Study finds friends are genetically similar
New study reveals how cholesterol promotes cancer
Revolutionary technology enables scientists to navigate and analyze complex 3D images
New technology reveals insights into mechanisms underlying amyloid diseases
Wild gorillas provide compelling evidence of olfactory communication in hominoids
  • Stickies: 0
  • News Articles: 157
  • Pages: 32
GPU 16 core approaching end of life.
[H]ard|Folding Administrator

Posts: 102
Points: 2,819,609
Work Units: 6,610

Posted: Mon Sep 30, 2013 01:25 am
GPU Core 16 is now approaching end of life status.

Our projects which use Core16 have completed and this means that Core16 is reaching its end of life, as the Core17 GPU core has some key features needed in new projects. We do not have an ETA for the last Core16 WU, but it is likely soon, i.e. in a week or two.
Reminder about aging cores (eg Core11, Core78)
[H]ard|Folding Administrator

Posts: 102
Points: 2,819,609
Work Units: 6,610

Posted: Tue Aug 27, 2013 12:26 am
Stanford has issued a reminder that certain cores are nearing "end of life" status.

One aspect which has dominated FAH for a decade is the continual push for new scientific approaches. This manifests itself in terms of new scientific cores. For example, the new GPU core (Core17) has brought huge speed improvements (especially to AMD GPUs) and involved a complete rewrite.

A negative consequence of this continuous push for improvement and progress is that newer cores often are restricted to more advanced hardware. To help utilize as much power as is available to FAH, we tend to continue projects with older cores, but eventually, the science they can do becomes too limiting, and we must retire them.

Full Article here
A peek into Core 17 benchmarking
[H]ard|Folding Administrator

Posts: 102
Points: 2,819,609
Work Units: 6,610

Posted: Tue Jul 30, 2013 05:13 am
Our primary goal with benchmarking is "equal points for equal work." However, making this process consistent over lots of different types of WUs and different types of hardware is tricky. We had an internal discussion about the PPD for two projects (7810 and 8900) recently and we thought donors might find these details interesting.

Full Article here
Computerized Brain-Fitness Program Improves Memory Of Older Adults
[H]ard|Folding Administrator

Posts: 102
Points: 2,819,609
Work Units: 6,610

Posted: Fri Jun 28, 2013 03:30 am
UCLA researchers have found that older adults who regularly used a brain-fitness program on a computer demonstrated significantly improved memory and language skills.

Full Article: here

Robo-Pets May Contribute to Quality of Life for Those With Dementia

A study has found that interacting with a therapeutic robot companion made people with mid- to late-stage dementia less anxious and also had a positive influence on their quality of life.

Full Article: here

Protein Identified That Contributes To Cognitive Decline In Alzheimer's Disease

Researchers at Columbia University Medical Center (CUMC) have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease. The findings, made in a mouse model of Alzheimer's, suggest that inhibiting this protein could prevent the neuronal damage and subsequent cognitive decline associated with the disease. The study was published this month in the online journal Nature Communications.

Full Article: here
Core 17 update
[H]ard|Folding Administrator

Posts: 102
Points: 2,819,609
Work Units: 6,610

Posted: Wed May 29, 2013 03:34 am
F@H GPU developer gives us a detailed video update of the new core 17 features.

Some of the key highlights are:
-Up to 120,000 PPD on GTX Titan, and 110,000 PPD on HD 7970
-Support for more diverse simulations
-Linux support on NVIDIA cards and 64bit OSes
-FAHBench updated to use the latest OpenMM and display version information

Full article and video here
  • Stickies: 0
  • News Articles: 157
  • Pages: 32
Administrator Council News Member

[H]ard|Folding Copyright © 2001 - 2014 by King_N,   [H]ard|OCP Copyright © 1998 - 2013 by Kyle Bennett

All trademarks used are properties of their respective owners. All rights reserved.