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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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  • Stickies: 0
  • News Articles: 156
  • Pages: 32
Reminder about aging cores (eg Core11, Core78)
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Tue Aug 27, 2013 12:26 am
Stanford has issued a reminder that certain cores are nearing "end of life" status.

Quote:
One aspect which has dominated FAH for a decade is the continual push for new scientific approaches. This manifests itself in terms of new scientific cores. For example, the new GPU core (Core17) has brought huge speed improvements (especially to AMD GPUs) and involved a complete rewrite.

A negative consequence of this continuous push for improvement and progress is that newer cores often are restricted to more advanced hardware. To help utilize as much power as is available to FAH, we tend to continue projects with older cores, but eventually, the science they can do becomes too limiting, and we must retire them.


Full Article here
A peek into Core 17 benchmarking
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Tue Jul 30, 2013 05:13 am
Quote:
Our primary goal with benchmarking is "equal points for equal work." However, making this process consistent over lots of different types of WUs and different types of hardware is tricky. We had an internal discussion about the PPD for two projects (7810 and 8900) recently and we thought donors might find these details interesting.


Full Article here
Computerized Brain-Fitness Program Improves Memory Of Older Adults
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Fri Jun 28, 2013 03:30 am
Quote:
UCLA researchers have found that older adults who regularly used a brain-fitness program on a computer demonstrated significantly improved memory and language skills.



Full Article: here



Robo-Pets May Contribute to Quality of Life for Those With Dementia

Quote:
A study has found that interacting with a therapeutic robot companion made people with mid- to late-stage dementia less anxious and also had a positive influence on their quality of life.



Full Article: here



Protein Identified That Contributes To Cognitive Decline In Alzheimer's Disease

Quote:
Researchers at Columbia University Medical Center (CUMC) have demonstrated that a protein called caspase-2 is a key regulator of a signaling pathway that leads to cognitive decline in Alzheimer's disease. The findings, made in a mouse model of Alzheimer's, suggest that inhibiting this protein could prevent the neuronal damage and subsequent cognitive decline associated with the disease. The study was published this month in the online journal Nature Communications.



Full Article: here
Core 17 update
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Wed May 29, 2013 03:34 am
F@H GPU developer gives us a detailed video update of the new core 17 features.

Quote:
Some of the key highlights are:
-Up to 120,000 PPD on GTX Titan, and 110,000 PPD on HD 7970
-Support for more diverse simulations
-Linux support on NVIDIA cards and 64bit OSes
-FAHBench updated to use the latest OpenMM and display version information




Full article and video here
Potential Therapy For Alzheimer's
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,473
Work Units: 6,593

Posted: Mon Apr 29, 2013 03:21 pm
Things have been pretty quiet this month, but I did manage to find a few interesting articles on Alzheimer's.


Alzheimer's Gene Discovery Offers Hope For Preventive Therapy

Quote:
Alzheimer's disease is the most common neurodegenerative disorder, affecting more than five million Americans, but currently there is no way to prevent, delay or stop its progression. A study published online by the Cell Press journal Neuron shows that a gene called CD33 contributes to Alzheimer's disease by inhibiting the ability of immune cells to remove toxic molecules in the brain.


Full Article here



Potential Therapeutic Targets Revealed For Late Onset Alzheimer's Disease

Quote:
Scientists from the Icahn School of Medicine at Mount Sinai, in collaboration with researchers from Icelandic Heart Association, Sage Bionetworks, and other institutions, have discovered that a network of genes involved in the inflammatory response in the brain is a crucial mechanism driving Late Onset Alzheimer's Disease (LOAD). The findings, published online in the journal Cell, provide new understanding of key pathways and genes involved in LOAD and valuable insights to develop potential therapies for the disease.


Full Article here



Potential Therapy For Alzheimer's Disease Revealed By Gene Networks In Brains Of Deceased Patients

Quote:
Most information about the cause of Alzheimer's disease is based on studies from animal models. Now, a study published by Cell Press in the journal Cell examines the brain tissue of deceased human patients and sheds light on dysfunctions in molecular networks in the brain that are at the root of Alzheimer's disease.


Full Article here
  • Stickies: 0
  • News Articles: 156
  • Pages: 32
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