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Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Active Members
Cancer News
Depressive Symptoms Are Linked To Early Death In Cancer Survivors
Non-Surgical Treatments For Multiple Tumors Move One Step Closer
Study Finds Broad Support For Rationing Of Some Types Of Cancer Care
Advanced Prostate Cancer Drug Xofigo Approved By FDA
Study Suggests Cutaneous Squamous Cell Carcinoma Carries Risk Of Metastasis And Death
Data Addressing Patient And Physician Barriers To Clinical Trials To Be Presented By Experts
Bankruptcy An Increased Risk Following Cancer Diagnosis
Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma
Molecular Profiling Timely For Tailoring Cancer Therapy
Exercise Lowers Risk Of Lung And Colorectal Cancer Among Middle Aged Men
Early Stage Testicular Cancer - Surveillance Is Best Follow-Up Strategy
Study Findings May Offer New Way To Kill Cancer Cells By Forcing Them Into An Alternative Programmed Death Pathway
In Preclinical Studies, New Drug Enhances Radiation Treatment For Brain Cancer
Chemists Demonstrate Nanoscale Alloys So Bright They Could Have Potential Medical Applications
FDA Approves New Lung Cancer Diagnostic "Cobas EGFR Mutation Test"
Cancer Metastasis Promoted By Tumor-Activated Protein
Signs Of Tobacco Smoke Still Found In Non-Smoking Hotel Rooms
Shared Decision Making And How Decision Aids Help Guide Choices For Cancer Screening
4 New Genetic Risk Factors Identified For Testicular Cancer
60 Years Of Data Suggest A Link Between Obesity And Height In Childhood And Endometrial Cancer In Adulthood
Link Suggested Between Tumor Suppressors And Starvation Survival
Study Examines Use Of Creative Arts Therapies Among Patients With Cancer
Egg Genome Is Reprogrammed To Match Sperm's With Or Without A Paternal Genome
Identifying The Social Needs Of Young People With Cancer
How Precise Chemical Modifications Turn Genes On And Off During Early Development -- And How Those Mechanisms Are Disrupted In Cancer
Alzheimer's News
News From Frontiers In Endocrinology, Microbiology, Physiology
Skin Cancer Link To Lower Risk Of Alzheimer's Disease, Says Study
Assessing The Efficacy Of Different Types Of Training Programs On Cognitive Performance In Elderly Patients
Detect Alzheimer's Disease Years Before Memory Loss And Cognitive Decline Become Apparent
Drug Improves Memory In Mice With Alzheimer's Disease
Obesity-Related Dementia Is Projected To Rise In England
Leukemia Drug Prevents Build-Up Of Toxic Brain Protein
Mutations In Genes That Regulate Cellular Metabolism Found In Families With Ataxia, Dementia And Reproductive Failure
A Patient's Right To Control Genomic Health Information
Association Between Alzheimer's Disease And Removal Of The Synaptic Protein ADAM10
Scientists Bring Clarity To How Most Alzheimer's Drugs Sharpen Brain Performance
Rethinking Therapeutic Strategies That Target APOE To Slow Amyloid Plaque Accumulation And Alzheimer's
Problems Processing Everyday Events Linked To Older Adults' Memory Lapses
Study Examines Cognitive Impairment In Families With Exceptional Longevity
How Environmental Stimuli And Brain Rhythms Generate Our Neuronal Maps Of The World
Study Finds Late-Life Depression Associated With Increased Risk For Dementia
Early Detection Of Alzheimer's Disease Expected In The Next Five To Ten Years
How Turning Down Synthesis Of A Protein Improves Nerve, Muscle Function In Common Neuropathy
Mediterranean Diet Helps Preserve Memory And Thinking Abilities
Potential Therapeutic Targets Revealed For Late Onset Alzheimer's Disease
Potential Therapy For Alzheimer's Disease Revealed By Gene Networks In Brains Of Deceased Patients
Alzheimer's Gene Discovery Offers Hope For Preventive Therapy
Molecular Changes Akin To Alzheimer's Discovered In Brain Following Mild Blast Injury
Berries Help Brain To Clear Toxic Accumulation
Mouse Model Sheds New Light On Early Stage Alzheimer's Disease
Biochemistry News
[H]ard|Folding News Articles
  • Stickies: 0
  • News Articles: 142
  • Pages: 29
New Futures In Biotech episode about Folding@home
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,411,832
Work Units: 6,094

Posted: Sat Aug 27, 2011 05:33 am
Vijay was a guest on the Twit Netcast, you can watch the interview here.

Also Vijay announced he just recieved the 2012 Michael and Kate Bárány Award.

Quote:
I have some good news. Due in large part to the work we've done with Folding@home, I've been named the recipient of the 2012 Michael and Kate Bárány Award for Young Investigators from the Biophysical Society for "developing field-defining and field-changing computational methods to produce leading theoretical models for protein and RNA folding." This was just annouced in the Biophysics Society newsletter and their web site hasn't been updated just yet for the 2012 awards.


Stanford also released a new paper this month.

Quote:
One major result is in the area of Alzheimer's Disease (paper #95). It is believed that Alzheimer's Disease results from the misfolding of the Abeta peptide. Understanding how Abeta misfolds could give us some key insights into how to cure Alzheimer's Disease. This paper experimentally tests a key prediction made in an earlier paper (paper #58: "Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach" by Nicholas W. Kelley, V. Vishal, Grant A. Krafft, and Vijay S. Pande. J. Chem. Phys. 129, 214707 (2008); DOI:10.1063/1.3010881). In this paper, we show experimentally that there appears to be a beta turn in the Abeta as predicted. This leads to a very stable form of misfolded Abeta which could be used as a starting point for a new Alzheimer's therapy. We are heavily pursuing this research direction at the moment.


You may view the paper here
New protein structure model to inhibit cancer
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,411,832
Work Units: 6,094

Posted: Sat Jul 30, 2011 07:20 am
Quote:
Researchers at the University of Hertfordshire have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.


Full Article here

Also researchers have found that Age-related brain shrinking is unique to humans

Quote:
As we age, our brains get lighter. By 80, the average human brain has lost 15% of its original weight.

People suffering with age-related dementias, such as Alzheimer's, experience even more shrinkage.

This weight loss is associated with a decline in the delicate finger-like structures of neurons, and in the connections between them.


Full Article here
Folding V7 Beta Client Update Status
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,411,832
Work Units: 6,094

Posted: Sun Jun 26, 2011 12:44 pm
Stanford has been working on the new v7.1.25 and v7.1.26 clients and have posted a status report.

Quote:
It's been a little while since our last v7 beta release (v7.1.24) and so I wanted to give donors some sense of what's going on. We've been working on internal testing of two releases past the current beta release and fixing bugs along the way. While we could in principle release v7.1.25 to open beta, there are enough todo items that we've decided to hold off a bit until it's a bit cleaner and further along. However, we're not going to hold off forever of course, just long enough for our developers to make some significant progress, especially since doing a release generates a lot of feedback, which takes developers away from coding.

To give some sense of where we are, here's the internal release notes for two recent builds (v7.1.25 and v7.1.26). Note that v7.1.26 is still in progress. Also, the #'s after the comment refer to our bug tracker. We have opened up the bug tracker, so one can see progress directly there on a daily basis if you're interested.



v7.1.26 (still under development):

* Failed upload attempt could cause WU to dump before it was expired. #679.

* Added AMD Radeon HD 6600 Series to GPU white-list.

* Fix failure to restart FAHControl in OSX when 'start minimized'. #649.

* Fixed a socket bug that could cause the loss of the end of a message.

* Build OSX client in 32-bit mode with Intel compiler.



v7.1.25:

* Hide 'Quit on window close' option in OSX.

* Fixed some problems with WU assign time and time offset calculations.

* Detect and ignore invalid assign time from older WS.

* Log computed WS time offset.

* Removed warning from Slot configuration about changing threads mid-run.

* Catch and log error accessing battery info in /sys on Linux

* Fix grayed out name and IP in client add after viewing local client. #640.

* Remove 'RS480 PCI-X Root Port' from GPU whitelist. #635

* Added a few new Radeon HD 6xxx cards.

* Added Nvidia GTX 590 device ID 0x1088 to whitelist.

* Increase Radeon HD 5xxxx and 6xxxx GPU type level by one. #653.

* Don't fail WS connections if all data was recieved even on net error.

* Print IP Address with 'Uploading' message.

* Fixes for OSX minimize and quit bugs. #649 & #659.

* Limit max CPUs per slot to system count. #652.

* Attempt to fix #654.

* Release system resources when querying OSX battery status. #650.

* Don't send 'auth' command from FAHControl if empty. #658.

* Fixed 'slot-add' NULL pointer exception. #666.

* Fixed 'log-updates start' error. #671.

* Fixed FAHClient script parsing bug. #676.

* Show 'Remote Access' tab in advanced mode. #648.

* Don't allow minimizing to sys-tray if it is not there. #670.

* Also print core return code numbers in hex. #677.

* Print times in ISO 8601 format. #664.

* Expire WUs in sending status.


Full Article here
Discovery could shed light on Alzheimers, Parkinsons and other neurodegenerative disorders
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,411,832
Work Units: 6,094

Posted: Sun May 22, 2011 09:11 am
Well it seems we've survived yet another judgement day. While that in itself is good news, it also seems that a discovery has been made in the battle against alzheimer's.

Quote:
No one knows the cause of most cases of Alzheimers, Parkinsons and other neurodegenerative disorders. But researchers have found that certain factors are consistently associated with these debilitating conditions. One is DNA damage by reactive oxygen species, highly destructive molecules usually formed as a byproduct of cellular respiration. Another is the presence of excessive levels of copper and iron in regions of the brain associated with the particular disorder.


Full Article here

New Diagnostic Criteria and Guidelines for Alzheimer
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,411,832
Work Units: 6,094

Posted: Mon Apr 25, 2011 04:28 pm
Quote:
Three expert international workgroups convened by the Alzheimers Association and the National Institute on Aging (NIA) have issued the first new criteria and guidelines to diagnose Alzheimers disease in 27 years. The new guidelines update, refine and broaden widely used guidelines published in 1984 by the Alzheimers Association (then known as the Alzheimers Disease and Related Disorders Association) and the National Institute of Neurological and Communicative Disorders and Stroke (now known as the National Institute of Neurological Disorders and Stroke).


Full Article here

  • Stickies: 0
  • News Articles: 142
  • Pages: 29
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