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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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 Rallor07/21/14 
 Jasjar07/20/14 
 shoerider07/17/14 
Rare form of tongue cancer suggests screening vigilance
The browning of white fat may be at the root of cancer-related wasting syndrome
Researching cancer's 'footprint' on our evolution
Structure of protein vital to cancer development is mapped
Bexarotene's effect on Alzheimer's may depend on severity of disease
Naloxegol being tested to counteract constipation caused by opioid painkillers
Could cat feces help cure cancer?
IBA receives FDA approval of its new compact gantry clearing the way for Proteus®ONE
A method developed for the more exact dosing of heavy ion irradiation in the case of cancer
Vulnerable moments for cancer cells' energy production revealed by game theory model
Decrease in HIV death rates from some causes
Exploiting gastric vulnerability: how Helicobacter pylori identifies and colonizes sites of small injury in the stomach
UV exposure: why do we ignore the health risks?
How strongly does tissue decelerate the therapeutic heavy ion beam?
Self-assembling nanoparticle could improve MRI scanning for cancer diagnosis
Improving tumour radiation therapy: when basic ions break DNA down
Tumor growth and metastasis controlled by new drug combo in mouse model
A powerful new technique for early diagnosis of cancer
New UK online video diary programme "Cancerstories" offers hope to patients and families with cancer
Potential new approach to brain cancer treatments and a better understanding of Parkinson's disease
Possible new type of immunotherapy: molecular 'eat now' signal makes cells devour dying neighbors
CellAct Pharma receives orphan drug designation in EU for CAP7.1 in biliary tract cancers
New technology developed for the diagnosis of cancer cells
How Cancer may be avoidable in the future
Genetic findings suggest new theory that turns cancer on its head
New studies presented at Alzheimer's Association International conference demonstrate diagnostic value of [<sup>18</sup>F]flutemetamol
Neuronal edema in Alzheimer's disease rats reduced by acupuncture and moxibustion
Bexarotene's effect on Alzheimer's may depend on severity of disease
Potential cause of preeclampsia may share links with disorders such as Alzheimer's
Can fish oil protect against brain damage caused by alcohol abuse?
Age-related changes in lateral ventricular width and periventricular white matter by diffusion tensor imaging
Older adults benefit from fish oil supplements which reduce incidence of cognitive decline, may improve memory function
Researchers seeking to smuggle pharmacological agents across the blood-brain barrier
Alzheimer's Association International Conference 2014 selected highlights
Gardens could benefit dementia patients and their carers
Signaling pathway for ginsenoside Rb1 promoting hippocampal neuronal neurite outgrowth
Alzheimer's disease not prevented by B vitamins
Genetic variant conveys significant protection against Alzheimer's disease
Memory and learning deficits restored in Alzheimer's mouse models
ANAVEX 3-71 highly effective and disease-modifying against all major Alzheimer's hallmarks in preclinical disease model
New data on possible protective behaviors and dementia risk factors emerges at Alzheimer's Association International Conference 2014
Could eye and smell tests offer early Alzheimer's diagnosis?
New analysis says Alzheimer's preventable in a third, not half of cases
Neurogenesis in Alzheimer's disease promoted by ADSCs transplantation
Four research trials show smell and eye tests offer potential to detect Alzheimer's early
Noninvasive retinal imaging device may provide highly predictive early detection of changes associated with Alzheimer's disease
Protein identified that causes breast cancer cells to metastasize
Smoking increases risk of dementia
Nasal mucosal inhalation of Alzheimer's disease vaccine attenuates Aβ1-42-induced cytotoxicity
Scientists investigate the cause of memory impairment in Alzheimer's Disease through GABA from reactive astrocytes
Life's imprint on DNA now mappable in single cell
Calorie restriction with resveratrol key to kick-starting cell health
Biomedical technologies may be improved by protein in squid skin
Gene identified that controls the timing of precisely ordered events during maturation
Structure of protein vital to cancer development is mapped
Scientists find ancient protein-building enzymes have undergone metamorphosis and evolved diverse new functions
Findings could revolutionise our understanding of timing during development
Study finds friends are genetically similar
New study reveals how cholesterol promotes cancer
Revolutionary technology enables scientists to navigate and analyze complex 3D images
New technology reveals insights into mechanisms underlying amyloid diseases
Wild gorillas provide compelling evidence of olfactory communication in hominoids
Plants respond to predators' chewing sounds
Scripps Florida scientists uncover new compounds that could affect circadian rhythm
Wake-up call for more research into cell metabolism
The 'yin and yang' of malaria parasite development
How tumors weaken blood barrier in brain cancer patients explained
Bone marrow hormone influences metabolism and health
Scientists probe DNA of 'Evolution Canyon' fruit flies and find drivers of change
Does green algae hold a genetic clue to the origin of the sexes?
The missing link between mental states and biological measures
What was believed to be noise is an important signaling factor
Tool maps origin of cancer with help of biological signatures
Gene discovered that activates stem cells for organ regeneration in Planarians
Obesity linked to type 2 diabetes by an absent protein
  • Stickies: 0
  • News Articles: 156
  • Pages: 32
New protein structure model to inhibit cancer
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,260
Work Units: 6,592

Posted: Sat Jul 30, 2011 07:20 am
Quote:
Researchers at the University of Hertfordshire have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.


Full Article here

Also researchers have found that Age-related brain shrinking is unique to humans

Quote:
As we age, our brains get lighter. By 80, the average human brain has lost 15% of its original weight.

People suffering with age-related dementias, such as Alzheimer's, experience even more shrinkage.

This weight loss is associated with a decline in the delicate finger-like structures of neurons, and in the connections between them.


Full Article here
Folding V7 Beta Client Update Status
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,260
Work Units: 6,592

Posted: Sun Jun 26, 2011 12:44 pm
Stanford has been working on the new v7.1.25 and v7.1.26 clients and have posted a status report.

Quote:
It's been a little while since our last v7 beta release (v7.1.24) and so I wanted to give donors some sense of what's going on. We've been working on internal testing of two releases past the current beta release and fixing bugs along the way. While we could in principle release v7.1.25 to open beta, there are enough todo items that we've decided to hold off a bit until it's a bit cleaner and further along. However, we're not going to hold off forever of course, just long enough for our developers to make some significant progress, especially since doing a release generates a lot of feedback, which takes developers away from coding.

To give some sense of where we are, here's the internal release notes for two recent builds (v7.1.25 and v7.1.26). Note that v7.1.26 is still in progress. Also, the #'s after the comment refer to our bug tracker. We have opened up the bug tracker, so one can see progress directly there on a daily basis if you're interested.



v7.1.26 (still under development):

* Failed upload attempt could cause WU to dump before it was expired. #679.

* Added AMD Radeon HD 6600 Series to GPU white-list.

* Fix failure to restart FAHControl in OSX when 'start minimized'. #649.

* Fixed a socket bug that could cause the loss of the end of a message.

* Build OSX client in 32-bit mode with Intel compiler.



v7.1.25:

* Hide 'Quit on window close' option in OSX.

* Fixed some problems with WU assign time and time offset calculations.

* Detect and ignore invalid assign time from older WS.

* Log computed WS time offset.

* Removed warning from Slot configuration about changing threads mid-run.

* Catch and log error accessing battery info in /sys on Linux

* Fix grayed out name and IP in client add after viewing local client. #640.

* Remove 'RS480 PCI-X Root Port' from GPU whitelist. #635

* Added a few new Radeon HD 6xxx cards.

* Added Nvidia GTX 590 device ID 0x1088 to whitelist.

* Increase Radeon HD 5xxxx and 6xxxx GPU type level by one. #653.

* Don't fail WS connections if all data was recieved even on net error.

* Print IP Address with 'Uploading' message.

* Fixes for OSX minimize and quit bugs. #649 & #659.

* Limit max CPUs per slot to system count. #652.

* Attempt to fix #654.

* Release system resources when querying OSX battery status. #650.

* Don't send 'auth' command from FAHControl if empty. #658.

* Fixed 'slot-add' NULL pointer exception. #666.

* Fixed 'log-updates start' error. #671.

* Fixed FAHClient script parsing bug. #676.

* Show 'Remote Access' tab in advanced mode. #648.

* Don't allow minimizing to sys-tray if it is not there. #670.

* Also print core return code numbers in hex. #677.

* Print times in ISO 8601 format. #664.

* Expire WUs in sending status.


Full Article here
Discovery could shed light on Alzheimers, Parkinsons and other neurodegenerative disorders
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,260
Work Units: 6,592

Posted: Sun May 22, 2011 09:11 am
Well it seems we've survived yet another judgement day. While that in itself is good news, it also seems that a discovery has been made in the battle against alzheimer's.

Quote:
No one knows the cause of most cases of Alzheimers, Parkinsons and other neurodegenerative disorders. But researchers have found that certain factors are consistently associated with these debilitating conditions. One is DNA damage by reactive oxygen species, highly destructive molecules usually formed as a byproduct of cellular respiration. Another is the presence of excessive levels of copper and iron in regions of the brain associated with the particular disorder.


Full Article here

New Diagnostic Criteria and Guidelines for Alzheimer
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,260
Work Units: 6,592

Posted: Mon Apr 25, 2011 04:28 pm
Quote:
Three expert international workgroups convened by the Alzheimers Association and the National Institute on Aging (NIA) have issued the first new criteria and guidelines to diagnose Alzheimers disease in 27 years. The new guidelines update, refine and broaden widely used guidelines published in 1984 by the Alzheimers Association (then known as the Alzheimers Disease and Related Disorders Association) and the National Institute of Neurological and Communicative Disorders and Stroke (now known as the National Institute of Neurological Disorders and Stroke).


Full Article here

Client Version 7(Beta)
King_N
[H]ard|Folding Administrator


Posts: 101
Points: 2,811,260
Work Units: 6,592

Posted: Tue Mar 29, 2011 08:41 pm
Stanford just released a new beta client for version 7.

Quote:
I am happy to announce that after many months of development and testing the new version 7 Folding@home client software is now available for open-beta testing. The V7 client is a complete rewrite of the previous client for Windows, OS-X and Linux with the following goals:

1.To make the installation and startup user-friendly for the novice.
2.To integrate the user interface into a single Monitor/Control program that manages the functionality previously contained in separate clients.
3.To create a forward-looking design that can be readily expanded to incorporate new Folding Cores without the need to issue new client releases.
4.To greatly improve previously problematic aspects including support for SMP, GPU, and the 3D viewer.


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  • Stickies: 0
  • News Articles: 156
  • Pages: 32
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