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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Discovery of navigation system used by cancer, nerve cells
New approach developed to identify 'drivers' of cancer
Cutting the liver piece by piece gives hope to patients with cancer that has spread from the intestine
Leukemia and other cancers could be treated more effectively with drug used for DNA repair defects
Study shows a direct correlation between smoking and mortality
Insights into the cancer epigenome have implications for treatment, prevention
Scientists map risk of premature menopause after cancer treatment
Repurposing anti-depressant medication to target medulloblastoma
Novel approach mimicks natural evolution with 'promiscuous reactions' to improve the diversity of drugs
New enzyme targets for selective cancer therapies
3D printers used to create custom medical implants
Unique alterations involving telomerase revealed by sequencing of rare kidney cancer
Surgery associated with better survival for patients with advanced laryngeal cancer
Genetics and lifestyle have a strong impact on biomarkers for inflammation and cancer
NSAIDs may halve breast cancer recurrence in overweight women
Blueprint for the next generation of chronic myeloid leukemia treatment
NICE clears path for patient access to Revlimid® (lenalidomide) for rare form of blood cancer
Blood test may revolutionize brain cancer diagnosis
Web-based app developed to predict glioma mutations
Transient axonal glycoprotein-1 induces apoptosis-related gene expression without triggering glioma apoptosis
Dasatinib, a leukemia drug, has the potential to treat many cancers
Gastric cancer: could Botox be an alternative to chemo?
Turkish man pleads guilty to importing illegal cancer drugs
Microfluidic device monitors key step in development of tumor metastases
Myc inhibition is an effective therapeutic strategy against the most aggressive of all brain tumors
APOE, diagnostic accuracy of CSF biomarkers for Alzheimer disease
Missing protein associated with early signs of dementia
Research underway to create pomegranate drug to stem Alzheimer's and Parkinson's
Cognitive impairment increases risk of stroke
Retinal thinning can be used as an early marker for frontotemporal dementia, prior to the onset of cognitive symptoms
Cognitive impairment 'associated with a higher risk of stroke'
New mouse line offers new insights for treatments of epilepsy, Alzheimer's
Alzheimer's disease: rAAV/ABAD-DP-6His attenuates oxidative stress induced injury of PC12 cells
Dementia risk increased for obese people in 30s, but reduced for obese seniors
Pulse pressure and elasticity of arteries in the brain mapped for arterial health and aging
Alzheimer's disease: are we close to finding a cure?
Zebrafish help to unravel Alzheimer's disease
Atypical antipsychotic drug use increases risk for acute kidney injury
Examining the brain's chromosomal make-up in relation to Alzheimer's disease
DNA methylation in brain 'linked to Alzheimer's disease'
Researchers find RNA-targeted drug candidate for Lou Gehrig's disease
Understanding of Alzheimer's disease improved by epigenetic breakthrough
Jet lag controlled by a single gene
Protein implicated in Alzheimer's disease has important treatment potential in genetic form of epilepsy
Decreased brain activity in Alzheimer's disease leads to decline in daily functioning
Yizhijiannao granules inhibit neuronal apoptosis in Alzheimer's disease
New small molecules target mutation in ALS and a form of dementia
Cognitive decline in older adults may be reduced by digital literacy
Study demonstrates key brain region in contextual memories
New target for treatment of neuronal injury in the hippocampus of rats with vascular dementia
Stem cell breakthrough for 'Cinderella cells'
Neanderthals and modern humans co-existed for thousands of years
Scientists grow fully functional thymus in mice from scratch
MRC publishes a review of the UK molecular pathology landscape
One of the biggest challenges for single-cell research is picking out only one cell from a collection of millions - problem solved
Treating pain by blocking the 'chili-pepper receptor'
Slippery material for lubricating joints inspired by nature
Scripps research institute chemists uncover powerful new click chemistry reactivity
Parasitic worms sniff out their victims as "cruisers" or "ambushers"
Scientists build first functional 3D brain tissue model
"Dimmer switch" drug idea could tackle schizophrenia
Cell signaling pathway linked to obesity and Type 2 diabetes
Probes that repair genes inspired by butterfly proboscis
The speed of a signal seals the fate of an embryonic cell
Scientists reproduce evolutionary changes by manipulating embryonic development of mice
New insights into why adolescents carry meningitis-causing bacteria
Self-assembling anti-cancer molecules created in minutes, like a self-assembling 'Lego Death Star'
Softening of human features 'coincided with technological breakthrough'
Chemists create nanofibers using unprecedented new method
Wound closure involves cooperative compression
Biomedical discoveries accelerated by see-through organs and bodies
Advances in maritime anti-fouling and biomedicine provided by barnacle cyprid adhesives
Mouse sperm form cooperative groups
See-through mice may improve diagnosis, treatment of human illness
Video explains why dogs smell each other's behinds
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  • News Articles: 158
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Award-winning research points toward Alzheimers vaccine
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,842,656
Work Units: 6,662

Posted: Wed Sep 28, 2011 06:46 pm
There really hasn't been any new news from Stanford this month, however I did run across this article dealing with research that could possibly lead to an Alzheimer's vaccine.

Quote:
AUGUSTA, Ga. An accomplice to the protein that causes plaque buildup in Alzheimers disease is the focus of a potential new treatment, according to research by a Georgia Health Sciences University graduate student.

In Alzheimers, the amyloid protein can accumulate in the brain instead of being eliminated by the bodys natural defenses, nestling between the neurons and forming impassable plaques.

Amyloid and the way it gets there could be targets for a new vaccine.


Full article here.
New Futures In Biotech episode about Folding@home
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,842,656
Work Units: 6,662

Posted: Sat Aug 27, 2011 05:33 am
Vijay was a guest on the Twit Netcast, you can watch the interview here.

Also Vijay announced he just recieved the 2012 Michael and Kate Bárány Award.

Quote:
I have some good news. Due in large part to the work we've done with Folding@home, I've been named the recipient of the 2012 Michael and Kate Bárány Award for Young Investigators from the Biophysical Society for "developing field-defining and field-changing computational methods to produce leading theoretical models for protein and RNA folding." This was just annouced in the Biophysics Society newsletter and their web site hasn't been updated just yet for the 2012 awards.


Stanford also released a new paper this month.

Quote:
One major result is in the area of Alzheimer's Disease (paper #95). It is believed that Alzheimer's Disease results from the misfolding of the Abeta peptide. Understanding how Abeta misfolds could give us some key insights into how to cure Alzheimer's Disease. This paper experimentally tests a key prediction made in an earlier paper (paper #58: "Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach" by Nicholas W. Kelley, V. Vishal, Grant A. Krafft, and Vijay S. Pande. J. Chem. Phys. 129, 214707 (2008); DOI:10.1063/1.3010881). In this paper, we show experimentally that there appears to be a beta turn in the Abeta as predicted. This leads to a very stable form of misfolded Abeta which could be used as a starting point for a new Alzheimer's therapy. We are heavily pursuing this research direction at the moment.


You may view the paper here
New protein structure model to inhibit cancer
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,842,656
Work Units: 6,662

Posted: Sat Jul 30, 2011 07:20 am
Quote:
Researchers at the University of Hertfordshire have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.


Full Article here

Also researchers have found that Age-related brain shrinking is unique to humans

Quote:
As we age, our brains get lighter. By 80, the average human brain has lost 15% of its original weight.

People suffering with age-related dementias, such as Alzheimer's, experience even more shrinkage.

This weight loss is associated with a decline in the delicate finger-like structures of neurons, and in the connections between them.


Full Article here
Folding V7 Beta Client Update Status
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,842,656
Work Units: 6,662

Posted: Sun Jun 26, 2011 12:44 pm
Stanford has been working on the new v7.1.25 and v7.1.26 clients and have posted a status report.

Quote:
It's been a little while since our last v7 beta release (v7.1.24) and so I wanted to give donors some sense of what's going on. We've been working on internal testing of two releases past the current beta release and fixing bugs along the way. While we could in principle release v7.1.25 to open beta, there are enough todo items that we've decided to hold off a bit until it's a bit cleaner and further along. However, we're not going to hold off forever of course, just long enough for our developers to make some significant progress, especially since doing a release generates a lot of feedback, which takes developers away from coding.

To give some sense of where we are, here's the internal release notes for two recent builds (v7.1.25 and v7.1.26). Note that v7.1.26 is still in progress. Also, the #'s after the comment refer to our bug tracker. We have opened up the bug tracker, so one can see progress directly there on a daily basis if you're interested.



v7.1.26 (still under development):

* Failed upload attempt could cause WU to dump before it was expired. #679.

* Added AMD Radeon HD 6600 Series to GPU white-list.

* Fix failure to restart FAHControl in OSX when 'start minimized'. #649.

* Fixed a socket bug that could cause the loss of the end of a message.

* Build OSX client in 32-bit mode with Intel compiler.



v7.1.25:

* Hide 'Quit on window close' option in OSX.

* Fixed some problems with WU assign time and time offset calculations.

* Detect and ignore invalid assign time from older WS.

* Log computed WS time offset.

* Removed warning from Slot configuration about changing threads mid-run.

* Catch and log error accessing battery info in /sys on Linux

* Fix grayed out name and IP in client add after viewing local client. #640.

* Remove 'RS480 PCI-X Root Port' from GPU whitelist. #635

* Added a few new Radeon HD 6xxx cards.

* Added Nvidia GTX 590 device ID 0x1088 to whitelist.

* Increase Radeon HD 5xxxx and 6xxxx GPU type level by one. #653.

* Don't fail WS connections if all data was recieved even on net error.

* Print IP Address with 'Uploading' message.

* Fixes for OSX minimize and quit bugs. #649 & #659.

* Limit max CPUs per slot to system count. #652.

* Attempt to fix #654.

* Release system resources when querying OSX battery status. #650.

* Don't send 'auth' command from FAHControl if empty. #658.

* Fixed 'slot-add' NULL pointer exception. #666.

* Fixed 'log-updates start' error. #671.

* Fixed FAHClient script parsing bug. #676.

* Show 'Remote Access' tab in advanced mode. #648.

* Don't allow minimizing to sys-tray if it is not there. #670.

* Also print core return code numbers in hex. #677.

* Print times in ISO 8601 format. #664.

* Expire WUs in sending status.


Full Article here
Discovery could shed light on Alzheimers, Parkinsons and other neurodegenerative disorders
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,842,656
Work Units: 6,662

Posted: Sun May 22, 2011 09:11 am
Well it seems we've survived yet another judgement day. While that in itself is good news, it also seems that a discovery has been made in the battle against alzheimer's.

Quote:
No one knows the cause of most cases of Alzheimers, Parkinsons and other neurodegenerative disorders. But researchers have found that certain factors are consistently associated with these debilitating conditions. One is DNA damage by reactive oxygen species, highly destructive molecules usually formed as a byproduct of cellular respiration. Another is the presence of excessive levels of copper and iron in regions of the brain associated with the particular disorder.


Full Article here

  • Stickies: 0
  • News Articles: 158
  • Pages: 32
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