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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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 Brian_Northcutt09/15/14 
 chinoquezada09/14/14 
 Riddeck09/13/14 
Researchers shed light on how breast implants may cause rare lymphoma
Neck surgery unnecessary for many throat cancer patients
For recurrent head and neck cancers a combination of targeted radiation and drug therapy is less toxic
Exercise can enhance tumor-shrinking effects of chemotherapy
More accurate treatment, greater patient comfort provided by new radiosurgery technology
Preserved mobility in malignant spinal cord compression
Cancer resistance may one day be treated with epigenetic drugs
New molecule 'allows umbilical cord stem cells to multiply'
Global team finds new genetic variants that raise risk of prostate cancer
Master regulator of cells' heat shock response identified
Rutgers Cancer Institute of New Jersey studying low participation in cancer screenings by South Asian population
Cell surface sugars can promote or inhibit cancer depending upon stage
A single protein can mean the difference between life-long chronic infection or cure for hepatitis
Potential for targeted treatments with new knowledge of genes driving bladder cancer
Final pieces to the circadian clock puzzle found
Specific baldness pattern linked with increased prostate cancer risk
American Association for Cancer Research releases 2014 cancer progress report: research is transforming lives
Cancer Council publishes first Australian guidelines on Barrett's Oesophagus and oesophageal adenocarcinoma
Research sheds light on cognitive losses seen with chemotherapy, autoimmune diseases
Study indicates that learning and memory defects are reversible in zebrafish model of neurofibromatosis, a human genetic disease
Detecting disease by the shadow it casts
Patient profiling may lead to earlier transition from active treatment to hospice care
New cellular connection makes scientific history
Breast cancer screening in over-70s 'may lead to overdiagnosis'
Patients with head and neck cancers resistant to cetuximab may benefit from an investigational drug
UB researchers corroborate the neuroprotective effects of Sirtuin 1 activation on mice with Alzheimer's disease
Concussion-related brain disease identified in living brain
Sedentary behavior 'may counteract brain benefits of exercise in older adults'
Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Measuring modified protein structures
The cell recognizes the buildup of misfolded proteins, offers insight into Alzheimer's, ALS, Huntington's, Parkinson's, and type 2 diabetes
Brain may 'work around' early Alzheimer's damage
The young brains of city dwellers harmed by air pollution
Discovery may lead to improved memory, cognitive function in Alzheimer's patients
In mouse model of Alzheimer's disease, targeted immune booster removes toxic proteins
sPIF protects against neuronal death and brain injury
Memory loss more common in people with blood type AB
Poor recording of physical health and medication could be causing dementia trials to fail
Neurodegenerative diseases can be caused by broken signals
Increased Alzheimer's risk linked to long-term benzodiazepine use
Gene 'may slow aging of entire body when activated in key organs'
Patients with advanced dementia continue receiving medications of questionable benefit
Apolipoprotein E and apolipoprotein CI are involved in cognitive impairment progression in Chinese late-onset Alzheimer's disease
Researchers track harmful immune reactions in the brain, suggest reason why HIV patients develop dementia
Association between diabetes mellitus, mild cognitive impairment and being middle aged and older
Memory and Alzheimer's disease
Older adults who volunteer are more likely to be happier and healthier
Pilot study of socially-assistive robots that help children with autism to learn imitative behavior
Late and early onset Alzheimer's affect brain function in similar way
Memory boosted by electric current to brain: finding has implications for stroke, Alzheimer's and brain injury
Pupil size shows reliability of decisions
Endocrine-related protein found to be master regulator in other important diseases
How do I smell? Much the same as how you see
Ebola virus protein offers potential drug target
Glaucoma cure may lie in targeting 'stiff cells' that impede fluid drainage
Is the pattern of brain folding a "fingerprint" for schizophrenia?
Scientists reset human stem cells in 'significant milestone' in medicine
Deactivating a cell protein may halt progress of rheumatoid arthritis
Gene 'may slow aging of entire body when activated in key organs'
Important regulators of immune cell response identified
Movable cytoskeleton membrane fabricated for first time
Genetic link identified between the circadian clock and seasonal timing
Body clock link could aid obesity treatments
Are females more susceptible to effects of marijuana?
Corals could provide a general model for understanding ciliary processes related to mass transport and disease
A call to investigators to study mysterious cloud-like collections in cells
Are molecular mechanisms to blame for how stress affects us?
New type of cell movement discovered
Research reveals mechanism behind cell protein remodeling within a family of cancers
Artificial virus improves delivery of new generations of pharmaceuticals
Stem cell breakthrough for 'Cinderella cells'
Neanderthals and modern humans co-existed for thousands of years
Scientists grow fully functional thymus in mice from scratch
MRC publishes a review of the UK molecular pathology landscape
One of the biggest challenges for single-cell research is picking out only one cell from a collection of millions - problem solved
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  • News Articles: 158
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Award-winning research points toward Alzheimers vaccine
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,857,126
Work Units: 6,701

Posted: Wed Sep 28, 2011 06:46 pm
There really hasn't been any new news from Stanford this month, however I did run across this article dealing with research that could possibly lead to an Alzheimer's vaccine.

Quote:
AUGUSTA, Ga. An accomplice to the protein that causes plaque buildup in Alzheimers disease is the focus of a potential new treatment, according to research by a Georgia Health Sciences University graduate student.

In Alzheimers, the amyloid protein can accumulate in the brain instead of being eliminated by the bodys natural defenses, nestling between the neurons and forming impassable plaques.

Amyloid and the way it gets there could be targets for a new vaccine.


Full article here.
New Futures In Biotech episode about Folding@home
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,857,126
Work Units: 6,701

Posted: Sat Aug 27, 2011 05:33 am
Vijay was a guest on the Twit Netcast, you can watch the interview here.

Also Vijay announced he just recieved the 2012 Michael and Kate Bárány Award.

Quote:
I have some good news. Due in large part to the work we've done with Folding@home, I've been named the recipient of the 2012 Michael and Kate Bárány Award for Young Investigators from the Biophysical Society for "developing field-defining and field-changing computational methods to produce leading theoretical models for protein and RNA folding." This was just annouced in the Biophysics Society newsletter and their web site hasn't been updated just yet for the 2012 awards.


Stanford also released a new paper this month.

Quote:
One major result is in the area of Alzheimer's Disease (paper #95). It is believed that Alzheimer's Disease results from the misfolding of the Abeta peptide. Understanding how Abeta misfolds could give us some key insights into how to cure Alzheimer's Disease. This paper experimentally tests a key prediction made in an earlier paper (paper #58: "Simulating oligomerization at experimental concentrations and long timescales: A Markov state model approach" by Nicholas W. Kelley, V. Vishal, Grant A. Krafft, and Vijay S. Pande. J. Chem. Phys. 129, 214707 (2008); DOI:10.1063/1.3010881). In this paper, we show experimentally that there appears to be a beta turn in the Abeta as predicted. This leads to a very stable form of misfolded Abeta which could be used as a starting point for a new Alzheimer's therapy. We are heavily pursuing this research direction at the moment.


You may view the paper here
New protein structure model to inhibit cancer
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,857,126
Work Units: 6,701

Posted: Sat Jul 30, 2011 07:20 am
Quote:
Researchers at the University of Hertfordshire have developed a new structural model of a protein, which makes it possible to develop more effective drugs to target diseases such as cancer, heart disease and influenza.


Full Article here

Also researchers have found that Age-related brain shrinking is unique to humans

Quote:
As we age, our brains get lighter. By 80, the average human brain has lost 15% of its original weight.

People suffering with age-related dementias, such as Alzheimer's, experience even more shrinkage.

This weight loss is associated with a decline in the delicate finger-like structures of neurons, and in the connections between them.


Full Article here
Folding V7 Beta Client Update Status
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,857,126
Work Units: 6,701

Posted: Sun Jun 26, 2011 12:44 pm
Stanford has been working on the new v7.1.25 and v7.1.26 clients and have posted a status report.

Quote:
It's been a little while since our last v7 beta release (v7.1.24) and so I wanted to give donors some sense of what's going on. We've been working on internal testing of two releases past the current beta release and fixing bugs along the way. While we could in principle release v7.1.25 to open beta, there are enough todo items that we've decided to hold off a bit until it's a bit cleaner and further along. However, we're not going to hold off forever of course, just long enough for our developers to make some significant progress, especially since doing a release generates a lot of feedback, which takes developers away from coding.

To give some sense of where we are, here's the internal release notes for two recent builds (v7.1.25 and v7.1.26). Note that v7.1.26 is still in progress. Also, the #'s after the comment refer to our bug tracker. We have opened up the bug tracker, so one can see progress directly there on a daily basis if you're interested.



v7.1.26 (still under development):

* Failed upload attempt could cause WU to dump before it was expired. #679.

* Added AMD Radeon HD 6600 Series to GPU white-list.

* Fix failure to restart FAHControl in OSX when 'start minimized'. #649.

* Fixed a socket bug that could cause the loss of the end of a message.

* Build OSX client in 32-bit mode with Intel compiler.



v7.1.25:

* Hide 'Quit on window close' option in OSX.

* Fixed some problems with WU assign time and time offset calculations.

* Detect and ignore invalid assign time from older WS.

* Log computed WS time offset.

* Removed warning from Slot configuration about changing threads mid-run.

* Catch and log error accessing battery info in /sys on Linux

* Fix grayed out name and IP in client add after viewing local client. #640.

* Remove 'RS480 PCI-X Root Port' from GPU whitelist. #635

* Added a few new Radeon HD 6xxx cards.

* Added Nvidia GTX 590 device ID 0x1088 to whitelist.

* Increase Radeon HD 5xxxx and 6xxxx GPU type level by one. #653.

* Don't fail WS connections if all data was recieved even on net error.

* Print IP Address with 'Uploading' message.

* Fixes for OSX minimize and quit bugs. #649 & #659.

* Limit max CPUs per slot to system count. #652.

* Attempt to fix #654.

* Release system resources when querying OSX battery status. #650.

* Don't send 'auth' command from FAHControl if empty. #658.

* Fixed 'slot-add' NULL pointer exception. #666.

* Fixed 'log-updates start' error. #671.

* Fixed FAHClient script parsing bug. #676.

* Show 'Remote Access' tab in advanced mode. #648.

* Don't allow minimizing to sys-tray if it is not there. #670.

* Also print core return code numbers in hex. #677.

* Print times in ISO 8601 format. #664.

* Expire WUs in sending status.


Full Article here
Discovery could shed light on Alzheimers, Parkinsons and other neurodegenerative disorders
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,857,126
Work Units: 6,701

Posted: Sun May 22, 2011 09:11 am
Well it seems we've survived yet another judgement day. While that in itself is good news, it also seems that a discovery has been made in the battle against alzheimer's.

Quote:
No one knows the cause of most cases of Alzheimers, Parkinsons and other neurodegenerative disorders. But researchers have found that certain factors are consistently associated with these debilitating conditions. One is DNA damage by reactive oxygen species, highly destructive molecules usually formed as a byproduct of cellular respiration. Another is the presence of excessive levels of copper and iron in regions of the brain associated with the particular disorder.


Full Article here

  • Stickies: 0
  • News Articles: 158
  • Pages: 32
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