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Folding@Home Information

Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



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Cancer News
Anti-Cancer Drug Reverses Alzheimer's Disease In Mice
Promising Early Results For Use Of Poliovirus Vaccine In Recurrent Glioblastoma
Radioactive Nanoparticles Developed That Target Cancer Cells
New Tumour Killer Developed By Scientists
Frequent Heartburn Increases Risk Of Throat Cancer By 78%
Grapefruit-Derived Nanovectors Provide A Secret Weapon In Medical Drug Delivery
Minimizing Hair Loss Due To Cancer Radiation Therapy
Researchers Develop Model For Better Testing, Targeting Of MPNST
Compound In Mediterranean Diet Makes Cancer Cells 'Mortal'
Reducing Your Risk Of Breast Cancer
Small Cancer Risk Following CT Scans In Childhood And Adolescence Confirmed
Epigenetic Regulators And NF-Kappa B May One Day Be Targeted For The Treatment Of Cancer
Software May Allow Doctors To Track Progression Of Cancer, Response To Treatment, And Risk Of Relapse
Outcome In Head And Neck Cancer Predicted By Genetic Diversity Within Tumors
Cancer Survivors Suffer Physical & Emotional Impairments Which Often Go Untreated
UK Aims To Make Genetic Testing Available To All Cancer Patients
Depressive Symptoms Are Linked To Early Death In Cancer Survivors
Non-Surgical Treatments For Multiple Tumors Move One Step Closer
Study Finds Broad Support For Rationing Of Some Types Of Cancer Care
Advanced Prostate Cancer Drug Xofigo Approved By FDA
Study Suggests Cutaneous Squamous Cell Carcinoma Carries Risk Of Metastasis And Death
Data Addressing Patient And Physician Barriers To Clinical Trials To Be Presented By Experts
Bankruptcy An Increased Risk Following Cancer Diagnosis
Blocking The Protein-Protein Interaction Which Causes Ewing Sarcoma
Molecular Profiling Timely For Tailoring Cancer Therapy
Alzheimer's News
Anti-Cancer Drug Reverses Alzheimer's Disease In Mice
Anti-Cancer Drug Viewed As Possible Alzheimer's Treatment Doesn't Work In UF Study
Class Of Drugs Discovered That Could Lead To The Development Of A Silver Bullet For Combatting Alzheimer's Disease
Alzheimer's Cause Found In Trigger Of Brain Protein Malfunction
Identification Of Molecular Trigger For Alzheimer's Disease
Aging Brains May Benefit More From Mediterranean Than Low Fat Diet
Relationship Discovered Between Sleep Apnea And Alzheimer's Disease
Mediterranean Diet Seems To Boost Ageing Brain Power
News From Frontiers In Endocrinology, Microbiology, Physiology
Skin Cancer Link To Lower Risk Of Alzheimer's Disease, Says Study
Assessing The Efficacy Of Different Types Of Training Programs On Cognitive Performance In Elderly Patients
Detect Alzheimer's Disease Years Before Memory Loss And Cognitive Decline Become Apparent
Drug Improves Memory In Mice With Alzheimer's Disease
Obesity-Related Dementia Is Projected To Rise In England
Leukemia Drug Prevents Build-Up Of Toxic Brain Protein
Mutations In Genes That Regulate Cellular Metabolism Found In Families With Ataxia, Dementia And Reproductive Failure
A Patient's Right To Control Genomic Health Information
Association Between Alzheimer's Disease And Removal Of The Synaptic Protein ADAM10
Scientists Bring Clarity To How Most Alzheimer's Drugs Sharpen Brain Performance
Rethinking Therapeutic Strategies That Target APOE To Slow Amyloid Plaque Accumulation And Alzheimer's
Problems Processing Everyday Events Linked To Older Adults' Memory Lapses
Study Examines Cognitive Impairment In Families With Exceptional Longevity
How Environmental Stimuli And Brain Rhythms Generate Our Neuronal Maps Of The World
Study Finds Late-Life Depression Associated With Increased Risk For Dementia
Early Detection Of Alzheimer's Disease Expected In The Next Five To Ten Years
Biochemistry News
[H]ard|Folding News Articles
  • Stickies: 0
  • News Articles: 142
  • Pages: 29
[H] Christmas
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,416,655
Work Units: 6,105

Posted: Wed Dec 23, 2009 11:13 pm
Not a whole lot to report this month, so I decided to share something that was posted on the forums in years long past.

I believe the author was relic, but I am not sure.

Quote:

Twas the Night Before a [H] Christmas

Twas the night before Christmas and all through the City
not a user was posting not even UncaMilty........

The cases were stacked by the hub with care,
in hopes that the Ti 500's soon would be there...

Frag2k was nestled all snug in his bed,
while visions of XP keychains danced in his head..

And Steve with his waterbox, and Kyle with his R.A.I.D.
had just settled down for a mid-Christmas upgrade...

When out on the forum there arose such a racket
Kyle grabbed his ban whip and prepared to crack it...

Away to the forums he flew like a flash
he eyed a new spammer and made his title Im on hash

Back to work Kyle went, his workbench lit by the monitor glow,
6 hours of testing and not a dang thing to show.....

Then what to Kyle's wondering eyes should appear?
none other than a Hooters girl and 8 frosty mugs of beer...

With a little tight rear, and next to nothing on,
Kyle knew in a moment it must be Sylvia St. John...

More rapid than SCSI his drink orders came,
as he whistled and hooted, and called them by name...

Gimme a Flat tire, a Guinness, a Miller and a Bud
A Michelob, a Coors, a Heineken and Shiner Bock is always good....

Three sheets to the wind he started overclocking his chips,
Until he installed the 4 in 1s and everything went to the pits....

As more and more XP chips ceased to function,
he threw them on the pile known as his keychain collection...

As the room filled with the smell of smoke and fried heatsink goo,
he passed out face down on his desk in a small pool of drool....

Several hours later stumbling through the den,
He had a revelation and ran looking for a conductive pen....

As he connected the L1's and ramped up the FSB,
he chuckled to himself with a maniacal glee....

He threw the bundled software in the bin marked trash
And said a silent prayer that maybe this one wouldn't crash...

His eyes how they sparkled! his expression how grim!
He downed another beer and hoped the drive would spin...

His motherboard was humming and starting to smoke,
He said to himself "oh crap, I think this ones gonna croak"....

He cursed the heat sink and gritted his teeth,
as the smoke curled around the chip like a wreath...

But wait he had one more XP sitting on a stray ratpad
He planned to clock this one higher, yes he was a bit mad....

This chip was under NDA but ready for action,
sent by AMD's PR department to get Kyle's reaction

With a flick of his pencil and a quick FSB bump,
he booted the system and felt a catch in his throat much like a lump....

He spoke not a word for fear it wouldn't work,
and when the system posted he stiffened with a jerk!

Clasping his hands in a silent prayer of thanks,
he thought the only thing better is Bin Laden on the business end of a tank

He installed 3D mark and Quake 3 too,
then went for a much needed run to the loo

The frame rates in Q3 were very impressive,
and he couldn't help but play a little excessive...

Fragging online some say is better than coke
but this weary overclocker said it was time for a smoke...

Jumping for joy and in bad need of a light,
He exclaimed "Merry Christmas to all and to all a good night!"


Merry Christmas and a Happy New Year to everyone.
New Cause for Alzheimer Disease
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,416,655
Work Units: 6,105

Posted: Sat Nov 28, 2009 07:08 pm
Quote:
Dr. Carme Espinet and colleagues at the University of Lleida, Lleida, Spain have discovered that a precursor to nerve growth factor (pro-NGF) may play a pathogenic role in Alzheimer disease. They present these findings in the December 2009 issue of The American Journal of Pathology.


Full article here
New F@H Servers and GPU3
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,416,655
Work Units: 6,105

Posted: Tue Oct 27, 2009 06:09 am
Stanford has ordered new servers to lighten the load.

Quote:

We've ordered a new class of servers which should make a big impact on FAH server load, and also allow us to release several new big projects with more WUs. We're very excited about this since we've been limited by server space recently, which has also lead to WU shortages. The new servers each have 24 x 2TB drives, so we should have plenty of space.


More Information here

Also some new core information.

Quote:

It will be called core_15 (the natural next number in the GPU series). The main changes there have been to incorporate the updated GPU code from OpenMM. OpenMM was based on our FAH GPU MD code to start, but has had several enhancements and additions.


More Information here
FAH work highlighted in Biomedical Computing Review
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,416,655
Work Units: 6,105

Posted: Fri Sep 25, 2009 01:47 pm
The Biomedical Computing Review has an article on folding at home in the Fall 2009 issue.

Quote:
Two key parts of FAH technology -- OpenMM (the software that powers FAH on GPUs) and MSMbuilder (the algorithms that FAH uses to stitch together hundreds of thousands of donor simulations to get coherent results) are highlighted in this months Biomedical Computing Review.


It is available in PDF format and is located here.
Function Upgrade Progressing
King_N
[H]ard|Folding Administrator


Posts: 87
Points: 2,416,655
Work Units: 6,105

Posted: Tue Aug 25, 2009 06:34 pm
The function upgrade is progressing rather smoothly, so far only a few minor bugs were found in the areas that had just been upgraded, these have all been squashed. Overall things appear to be working faster in the areas that have been upgraded thus far.

Please remember that there is no such thing as bug free, especially with the amount of code being worked on. No matter how hard you try no human is perfect, thus nothing created by a human is perfect. I do try to keep bugs minimal and do try to squash them within a short time of when they are discovered.

If you do find a bug, please remember to shoot me a PM.
  • Stickies: 0
  • News Articles: 142
  • Pages: 29
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