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Stanford's goal: to understand protein folding, protein aggregation, and related diseases.



What are proteins and why do they "fold"? Proteins are biology's workhorses -- its "nanomachines." Before proteins can carry out their biochemical function, they remarkably assemble themselves, or "fold." The process of protein folding, while critical and fundamental to virtually all of biology, remains a mystery. Moreover, perhaps not surprisingly, when proteins do not fold correctly (i.e. "misfold"), there can be serious effects, including many well known diseases, such as Alzheimer's, Mad Cow (BSE), CJD, ALS, and Parkinson's disease.

What does Folding@Home do? Folding@Home is a distributed computing project which studies protein folding, misfolding, aggregation, and related diseases. Stanford uses novel computational methods and large scale distributed computing, to simulate timescales thousands to millions of times longer than previously achieved. This has allowed us to simulate folding for the first time, and to now direct Stanford's approach to examine folding related disease.



How to Join | Project Faqs | Project Add-ons | Statistics | Download Client
New Members
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 Brian_Northcutt09/15/14 
 chinoquezada09/14/14 
 Riddeck09/13/14 
 James_Resiter09/12/14 
New molecule 'allows umbilical cord stem cells to multiply'
Global team finds new genetic variants that raise risk of prostate cancer
Master regulator of cells' heat shock response identified
Rutgers Cancer Institute of New Jersey studying low participation in cancer screenings by South Asian population
Cell surface sugars can promote or inhibit cancer depending upon stage
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Final pieces to the circadian clock puzzle found
Specific baldness pattern linked with increased prostate cancer risk
American Association for Cancer Research releases 2014 cancer progress report: research is transforming lives
Cancer Council publishes first Australian guidelines on Barrett's Oesophagus and oesophageal adenocarcinoma
Research sheds light on cognitive losses seen with chemotherapy, autoimmune diseases
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Detecting disease by the shadow it casts
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New cellular connection makes scientific history
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Patients with head and neck cancers resistant to cetuximab may benefit from an investigational drug
'Electronic skin' could revolutionize breast cancer detection
Small cell lung cancer: chest radiotherapy 'prolongs survival, reduces recurrence'
New mechanism that inhibits the activity of proteasomes paves the way for a new generation of chemotherapies
Why damaged DNA contributes to cancer and other age-related illnesses
Patients with high-risk endometrial cancer benefit from radiation therapy with concurrent chemotherapy after surgery
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DNA sequence of Ashkenazi Jews mapped
Sedentary behavior 'may counteract brain benefits of exercise in older adults'
Dementia risk reduction through tobacco control and better prevention, detection and control of hypertension and diabetes
Measuring modified protein structures
The cell recognizes the buildup of misfolded proteins, offers insight into Alzheimer's, ALS, Huntington's, Parkinson's, and type 2 diabetes
Brain may 'work around' early Alzheimer's damage
The young brains of city dwellers harmed by air pollution
Discovery may lead to improved memory, cognitive function in Alzheimer's patients
In mouse model of Alzheimer's disease, targeted immune booster removes toxic proteins
sPIF protects against neuronal death and brain injury
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Neurodegenerative diseases can be caused by broken signals
Increased Alzheimer's risk linked to long-term benzodiazepine use
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Apolipoprotein E and apolipoprotein CI are involved in cognitive impairment progression in Chinese late-onset Alzheimer's disease
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Association between diabetes mellitus, mild cognitive impairment and being middle aged and older
Memory and Alzheimer's disease
Older adults who volunteer are more likely to be happier and healthier
Pilot study of socially-assistive robots that help children with autism to learn imitative behavior
Late and early onset Alzheimer's affect brain function in similar way
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Movable cytoskeleton membrane fabricated for first time
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A call to investigators to study mysterious cloud-like collections in cells
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Stem cell breakthrough for 'Cinderella cells'
Neanderthals and modern humans co-existed for thousands of years
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New Diagnostic Criteria and Guidelines for Alzheimer
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,856,487
Work Units: 6,698

Posted: Mon Apr 25, 2011 04:28 pm
Quote:
Three expert international workgroups convened by the Alzheimers Association and the National Institute on Aging (NIA) have issued the first new criteria and guidelines to diagnose Alzheimers disease in 27 years. The new guidelines update, refine and broaden widely used guidelines published in 1984 by the Alzheimers Association (then known as the Alzheimers Disease and Related Disorders Association) and the National Institute of Neurological and Communicative Disorders and Stroke (now known as the National Institute of Neurological Disorders and Stroke).


Full Article here

Client Version 7(Beta)
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,856,487
Work Units: 6,698

Posted: Tue Mar 29, 2011 08:41 pm
Stanford just released a new beta client for version 7.

Quote:
I am happy to announce that after many months of development and testing the new version 7 Folding@home client software is now available for open-beta testing. The V7 client is a complete rewrite of the previous client for Windows, OS-X and Linux with the following goals:

1.To make the installation and startup user-friendly for the novice.
2.To integrate the user interface into a single Monitor/Control program that manages the functionality previously contained in separate clients.
3.To create a forward-looking design that can be readily expanded to incorporate new Folding Cores without the need to issue new client releases.
4.To greatly improve previously problematic aspects including support for SMP, GPU, and the 3D viewer.


Download Available here.
New SMP clients available.
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,856,487
Work Units: 6,698

Posted: Mon Feb 28, 2011 07:56 am
Stanford just released the new 6.34 SMP clients.

Download Available here



New Client Released
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,856,487
Work Units: 6,698

Posted: Sat Jan 29, 2011 10:44 am
Stanford just released GPU3 client version 641.

Quote:
The changes to this version of the client include the addition of a -forcegpu flag ='nvidia_g80_1.0' ; this flag will signal a compute capability of 1.0 (GPU species=10); if the flag ''nvidia_g80' is used the compute capability will be reported as 1.1 (GPU species=11). Also a pop-up dialog box now appears reporting an error, if the -forcegpu flag is unrecognized; the client then exits.


Download Available here



Everything back to normal
King_N
[H]ard|Folding Administrator


Posts: 103
Points: 2,856,487
Work Units: 6,698

Posted: Fri Dec 31, 2010 03:44 am
Stanford appears to have compleated thier server maintenance, the maintenance they ran did cause a few glitches on this end however everything appears to be back to normal once again.

Have a Happy New Year everyone.
  • Stickies: 0
  • News Articles: 158
  • Pages: 32
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